[Physiological problems of manned mission to Mars].

Harsh environment and extreme factors related to the supposed exploration missions to Mars are considered as well as concomitant human organism reactions. Further investigations are required to get insight into the effects of gravity ranging from microgravity to hypogravity to hypergravity the crew will be exposed to during this voyage. A special emphasis should be placed on the studies of artificial gravity as an alternative to the existing in-flight countermeasures. Other issues to be attended include transitory states of human organism as a response to changes in gravity, effects of ionizing radiation and synergy of the variety of flight factors, and mechanisms of the hypomagnetic effects.