| Literature DB >> 17647265 |
Abstract
Stem cells have two common properties: the capacity for self-renewal and the potential to differentiate into one or more specialized cell types. In general, stem cells can be divided into two broad categories: adult (somatic) stem cells and embryonic stem cells. Recent evidence suggested that tumors may contain "cancer stem cells" with indefinite potential for self-renewal. In this review, we will focus on the molecular mechanisms regulating embryonic stem cell self-renewal and differentiation, and discuss how these mechanisms may be relevant in cancer cells. Copyright 2007 Wiley-Liss, Inc.Entities:
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Year: 2008 PMID: 17647265 DOI: 10.1002/jcb.21460
Source DB: PubMed Journal: J Cell Biochem ISSN: 0730-2312 Impact factor: 4.429