Literature DB >> 17647214

Synthesis of novel 1-pyrazolylpyridin-2-ones as potential anti-inflammatory and analgesic agents.

Magda M F Ismail1, Yousry A Ammar, Heba S A El-Zahaby, Sally I Eisa, Saber El-Sayed Barakat.   

Abstract

A new series of 4-alkyl/aryl-2-oxo-1-pyrazolyl-1,2-dihydropyridine-3-carbonitriles, pyrazolo[3,4-b]pyridine-5-carbonitriles and pyrido[2,3-d]pyrimidine-6-carbonitriles have been synthesized and tested for their anti-inflammatory and analgesic activities. Among the tested compounds, 3e and 8b exhibited comparable anti-inflammatory activity to the standard (indomethacin). Compounds 5, 7a, and 8b displayed potent analgesic activity. Detailed syntheses, spectroscopic and biological data are reported.

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Year:  2007        PMID： 17647214     DOI： 10.1002/ardp.200600197

Source DB:  PubMed          Journal:  Arch Pharm (Weinheim)        ISSN： 0365-6233            Impact factor:   3.751


  5 in total

1.  2-[(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino]-1-methyl-2-oxoethyl pyrrolidine-1-carbodithio-ate.

Authors:  Mehmet Akkurt; Nuray Ulusoy Güzeldemirci; Nesrin Cesur; Orhan Büyükgüngör
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-11-13

Review 2.  A review on the development of urease inhibitors as antimicrobial agents against pathogenic bacteria.

Authors:  Yuri F Rego; Marcelo P Queiroz; Tiago O Brito; Priscila G Carvalho; Vagner T de Queiroz; Ângelo de Fátima; Fernando Macedo
Journal:  J Adv Res       Date:  2018-05-04       Impact factor: 10.479

3.  The Role of Pyrazolopyridine Derivatives on Different Steps of Herpes Simplex Virus Type-1 In Vitro Replicative Cycle.

Authors:  Milene D Miranda; Otávio Augusto Chaves; Alice S Rosa; Alexandre R Azevedo; Luiz Carlos da Silva Pinheiro; Vinicius C Soares; Suelen S G Dias; Juliana L Abrantes; Alice Maria R Bernardino; Izabel C P Paixão; Thiago Moreno L Souza; Carlos Frederico L Fontes
Journal:  Int J Mol Sci       Date:  2022-07-23       Impact factor: 6.208

4.  Microwave assisted synthesis of novel pyrazolone derivatives attached to a pyrimidine moiety and evaluation of their anti-inflammatory, analgesic and antipyretic activities.

Authors:  Rishikesh V Antre; A Cendilkumar; Divakar Goli; Ganesh S Andhale; Rajesh J Oswal
Journal:  Saudi Pharm J       Date:  2011-06-25       Impact factor: 4.330

5.  Multi-component one-pot synthesis and antimicrobial activities of 3-methyl-1,4-diphenyl-7-thioxo-4,6,8,9-tetrahydro-pyrazolo[5,4-b]pyrimidino[5,4-e]pyridine-5-one and related derivatives.

Authors:  Talaat I El-Emary; Shawkat A Abd El-Mohsen
Journal:  Molecules       Date:  2012-12-06       Impact factor: 4.411
  5 in total

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