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Literature DB >> 17647111

Metastasis and stem cell pathways.

Abstract

Recent studies have described a small population of self-renewing and multipotent cells within tumors termed "cancer stem cells." These cells share many traits with somatic and embryonic stem cells and are thought to be responsible for driving tumor progression in a growing list of neoplastic diseases. Cells within solid tumors encounter hypoxia due to poor vascular function. Both long-standing and emerging data describe hypoxic effects on somatic and embryonic stem cells, and it is likely that hypoxia also has profound effects on cancer stem cells. These effects include the activation of pathways that induce the dedifferentiation of cancer cells, the maintenance of stem cell identity, and increased metastatic potential. Hypoxia may contribute to tumor progression by specifically impacting these pathways in cancer stem cells.

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 17647111 PMCID： PMC3215288 DOI： 10.1007/s10555-007-9053-3

Source DB: PubMed Journal: Cancer Metastasis Rev ISSN： 0167-7659 Impact factor: 9.264

90 in total

1. Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia.

Authors: Abderrahmane Kaidi; Ann Caroline Williams; Christos Paraskeva
Journal: Nat Cell Biol Date: 2007-01-14 Impact factor: 28.824

2. A perivascular niche for brain tumor stem cells.

Authors: Christopher Calabrese; Helen Poppleton; Mehmet Kocak; Twala L Hogg; Christine Fuller; Blair Hamner; Eun Young Oh; M Waleed Gaber; David Finklestein; Meredith Allen; Adrian Frank; Ildar T Bayazitov; Stanislav S Zakharenko; Amar Gajjar; Andrew Davidoff; Richard J Gilbertson
Journal: Cancer Cell Date: 2007-01 Impact factor: 31.743

Review 3. Beyond tumorigenesis: cancer stem cells in metastasis.

Authors: Feng Li; Benjamin Tiede; Joan Massagué; Yibin Kang
Journal: Cell Res Date: 2007-01 Impact factor: 25.617

Review 4. mTOR and cancer therapy.

Authors: J B Easton; P J Houghton
Journal: Oncogene Date: 2006-10-16 Impact factor: 9.867

5. RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha.

Authors: Ye V Liu; Jin H Baek; Huafeng Zhang; Roberto Diez; Robert N Cole; Gregg L Semenza
Journal: Mol Cell Date: 2007-01-26 Impact factor: 17.970

6. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.

Authors: Shideng Bao; Qiulian Wu; Roger E McLendon; Yueling Hao; Qing Shi; Anita B Hjelmeland; Mark W Dewhirst; Darell D Bigner; Jeremy N Rich
Journal: Nature Date: 2006-10-18 Impact factor: 49.962

7. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice.

Authors: Catherine A O'Brien; Aaron Pollett; Steven Gallinger; John E Dick
Journal: Nature Date: 2006-11-19 Impact factor: 49.962

8. Identification and expansion of human colon-cancer-initiating cells.

Authors: Lucia Ricci-Vitiani; Dario G Lombardi; Emanuela Pilozzi; Mauro Biffoni; Matilde Todaro; Cesare Peschle; Ruggero De Maria
Journal: Nature Date: 2006-11-19 Impact factor: 49.962

9. Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype.

Authors: Linda Holmquist-Mengelbier; Erik Fredlund; Tobias Löfstedt; Rosa Noguera; Samuel Navarro; Helén Nilsson; Alexander Pietras; Johan Vallon-Christersson; Ake Borg; Katarina Gradin; Lorenz Poellinger; Sven Påhlman
Journal: Cancer Cell Date: 2006-11 Impact factor: 31.743

10. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity.

Authors: John D Gordan; Jessica A Bertout; Cheng-Jun Hu; J Alan Diehl; M Celeste Simon
Journal: Cancer Cell Date: 2007-04 Impact factor: 31.743

26 in total

Review 1. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy.

Authors: Gregg L Semenza
Journal: Trends Pharmacol Sci Date: 2012-03-06 Impact factor: 14.819

2. EGCG inhibits growth of human pancreatic tumors orthotopically implanted in Balb C nude mice through modulation of FKHRL1/FOXO3a and neuropilin.

Authors: Sharmila Shankar; Luke Marsh; Rakesh K Srivastava
Journal: Mol Cell Biochem Date: 2012-09-13 Impact factor: 3.396

3. HIF-1α and HSP90: target molecules selected from a tumorigenic papillary thyroid carcinoma cell line.

Authors: Ji-Hun Mo; Ik J Choi; Woo-Jin Jeong; Eun-Hui Jeon; Soon-Hyun Ahn
Journal: Cancer Sci Date: 2012-01-09 Impact factor: 6.716

Review 4. The tumor microenvironment and its contribution to tumor evolution toward metastasis.

Authors: Girieca Lorusso; Curzio Rüegg
Journal: Histochem Cell Biol Date: 2008-11-06 Impact factor: 4.304

5. Cripto-1 is required for hypoxia to induce cardiac differentiation of mouse embryonic stem cells.

Authors: Caterina Bianco; Catherine Cotten; Enza Lonardo; Luigi Strizzi; Christina Baraty; Mario Mancino; Monica Gonzales; Kazuhide Watanabe; Tadahiro Nagaoka; Colin Berry; Andrew E Arai; Gabriella Minchiotti; David S Salomon
Journal: Am J Pathol Date: 2009-10-15 Impact factor: 4.307