| Literature DB >> 17645891 |
R M Gil da Costa1, A Rema, P Payo-Puente, F Gärtner.
Abstract
Sebaceous gland carcinoma is a common tumour in male gerbils but, to date, no information is available on its immunohistochemical properties. This report describes the histopathological and immunohistochemical features of such a tumour from a 4.5-year-old male gerbil. The tumour immunoreactivity profile was studied in respect of p53 protein, CEA, EMA, c-erbB-2, cytokeratin (CK) 14 and the CKs detected by AE1/AE3 antibodies (i.e. high molecular weight CKs 1, 2, 3, 4, 5, 6, 10, 14, 15 and 16, and low molecular weight CKs 7, 8 and 19). The differences observed in p53 and c-erbB-2 immunolabelling between carcinomatous and hyperplastic areas suggest that p53 mutations and amplification of c-erbB-2 may play a significant role in the oncogenesis of sebaceous gland carcinoma in the gerbil.Entities:
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Year: 2007 PMID： 17645891 DOI： 10.1016/j.jcpa.2006.04.006
Source DB: PubMed Journal: J Comp Pathol ISSN： 0021-9975 Impact factor: 1.311