| Literature DB >> 17643991 |
Mahendra Ramesh Shiradkar1, Mallikarjuna Bandrehally Padhalingappa, Sastry Bhetalabhotala, Kalyan Chakravarthy Akula, Dattu Anna Tupe, Raghotham Reddy Pinninti, Suman Thummanagoti.
Abstract
Based on the earlier results of our in-house database and compound library, a series of novel clubbed thienyl triazoles was designed which may emerge as potential cdk5/p25 inhibitors, for the treatment of Alzheimer's disease. A benign synthesis was planned so as to take an advantage of MAOS (Microwave Assisted Organic Synthesis) method. Evaluation of the SAR of this series has allowed the identification of compounds 4, 5, 7 and 8 from series I while 13, 14, 16 and 17 from series II as significant cdk5/p25 inhibitors and thus have potential as possible treatments for Alzheimer's disease.Entities:
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Year: 2007 PMID： 17643991 DOI： 10.1016/j.bmc.2007.06.053
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641