Literature DB >> 17643882

Distribution of dimethoate in the body after a fatal organophosphate intoxication.

F A Tarbah1, A M Shaheen, F A Benomran, A I Hassan, Th Daldrup.   

Abstract

Many organophosphate pesticides (OPs) such as dimethoate are used to eradicate household pests, and those occurring in agriculture and forestry sectors. Combinations of two or more different insecticides have been manufactured to increase their effectiveness. A case of death is presented as suspected organophosphates intoxication. Autopsy was unremarkable except for grayish fluid in the stomach, with garlicky odor. A systematic toxicological analysis on post-mortem specimens revealed high concentrations of dimethoate in blood 38 microg/mL, urine 0.47 microg/mL, brain 2.2 microg/g, myocardial muscle 7.6 microg/g, liver 4.6 microg/g, lung 7.6 microg/g, skeletal muscle 21 microg/g, kidney 55 microg/g and gall bladder 31 microg/g. Blood alcohol was 2.85 g/L, cyclohexanone and cyclohexanol were also detected in the blood but not quantified. The cause of death was determined as organophosphate intoxication.

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Year:  2007        PMID: 17643882     DOI: 10.1016/j.forsciint.2007.04.232

Source DB:  PubMed          Journal:  Forensic Sci Int        ISSN: 0379-0738            Impact factor:   2.395


  4 in total

Review 1.  Organophosphorus pesticide determination in biological specimens: bioanalytical and toxicological aspects.

Authors:  Sofia Soares; Tiago Rosado; Mário Barroso; Duarte Nuno Vieira; Eugenia Gallardo
Journal:  Int J Legal Med       Date:  2019-07-12       Impact factor: 2.686

2.  Antioxidant-rich date palm fruit extract inhibits oxidative stress and nephrotoxicity induced by dimethoate in rat.

Authors:  Emna Behija Saafi-Ben Salah; Amira El Arem; Mouna Louedi; Mongi Saoudi; Abdelfattah Elfeki; Abdelfattah Zakhama; Mohamed Fadhel Najjar; Mohamed Hammami; Lotfi Achour
Journal:  J Physiol Biochem       Date:  2011-10-08       Impact factor: 4.158

3.  Hepato-protective potential of methanol extract of leaf of Ziziphus mucronata (ZMLM) against dimethoate toxicity: biochemical and histological approach.

Authors:  T E Kwape; P Chaturvedi; J M Kamau; S George
Journal:  Ghana Med J       Date:  2013-09

4.  Suicidal poisoning with mercaptodimethur-morphological findings and toxicological analysis.

Authors:  A Thierauf; H Gnann; M Bohnert; B Vennemann; V Auwärter; W Weinmann
Journal:  Int J Legal Med       Date:  2009-01-16       Impact factor: 2.686

  4 in total

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