| Literature DB >> 17643559 |
T N Mazzola1, M T N Da Silva, Y M F Moreno, S C B S Lima, E F Carniel, A M Morcillo, M A R G M Antonio, M L Zanolli, A Aranha Netto, M H Blotta, I Raw, M M S Vilela.
Abstract
Cell-mediated immune responses to BCG vaccine were evaluated in 7-month-old infants vaccinated with intradermal combined BCG and Hepatitis B or intradermal BCG and intramuscular Hepatitis B at birth. Peripheral blood mononuclear cell cultures from both groups showed CD4(+), CD8(+) and remarkable gammadelta(+) T cell BCG-specific proliferation, without significant differences. Also, IL-10, IL-12, IFN-gamma and TNF-alpha concentrations in culture supernatants, measured by ELISA, were similar. The results suggested that the combined BCG and Hepatitis B vaccine was as immunogenic as BCG separated from Hepatitis B vaccine.Entities:
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Year: 2007 PMID： 17643559 DOI： 10.1016/j.vaccine.2007.06.039
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641