| Literature DB >> 17643557 |
Balázs Balogh1, Balázs Jójárt, Zsolt Wágner, Péter Kovács, Gáspár Máté, Klára Gyires, Zoltán Zádori, György Falkay, Arpád Márki, Béla Viskolcz, Péter Mátyus.
Abstract
Three-dimensional structure-activity relationship studies of alpha2a-adrenoceptor agonists were carried out by Distance Comparison (DISCOthech) and Comparative Molecular Field Analysis (CoMFA) methods to define the pharmacophore and a quantitative model, respectively, of this class of compounds. The statistical validation of the CoMFA model indicates its high predictive performance for binding affinities of new alpha2a-adrenoceptor agonists.Entities:
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Year: 2007 PMID： 17643557 DOI： 10.1016/j.neuint.2007.05.021
Source DB: PubMed Journal: Neurochem Int ISSN： 0197-0186 Impact factor: 3.921