Literature DB >> 17643266

The effects of vigabatrin on spike and wave discharges in WAG/Rij rats.

Brigitte M Bouwman1, Piotr Suffczynski, Inna S Midzyanovskaya, Eric Maris, Philip L C van den Broek, Clementina M van Rijn.   

Abstract

The effects of vigabatrin, which increases GABA concentrations by inhibiting GABA transaminase, on spike and wave discharges (SWDs) in the electroencephalogram of WAG/Rij rats were studied. Vigabatrin increased the incidence and duration of the SWDs, suggesting a quantitative GABA(A)ergic involvement in the mechanism(s) underlying the starting and stopping of an ongoing SWD. Also, vigabatrin decreased the SWD peak frequency, suggesting an important role of GABA(B) in the mechanism(s) underlying the peak frequency of the SWDs. Vigabatrin gradually changed the course of the hazard rates of the SWD durations, suggesting a qualitative GABAergic role in the mechanism(s) underlying the stopping of an ongoing SWD.

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Year:  2007        PMID： 17643266     DOI： 10.1016/j.eplepsyres.2007.06.006

Source DB:  PubMed          Journal:  Epilepsy Res        ISSN： 0920-1211            Impact factor:   3.045


  6 in total

Review 1.  GABA(A) receptor physiology and its relationship to the mechanism of action of the 1,5-benzodiazepine clobazam.

Authors:  Raman Sankar
Journal:  CNS Drugs       Date:  2012-03-01       Impact factor: 5.749

2.  Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats.

Authors:  V D'Amore; I Santolini; C M van Rijn; F Biagioni; G Molinaro; A Prete; P J Conn; C W Lindsley; Y Zhou; P N Vinson; A L Rodriguez; C K Jones; S R Stauffer; F Nicoletti; G van Luijtelaar; R T Ngomba
Journal:  Neuropharmacology       Date:  2012-06-15       Impact factor: 5.250

3.  Non-neuronal, slow GABA signalling in the ventrobasal thalamus targets δ-subunit-containing GABA(A) receptors.

Authors:  Cristina Jiménez-González; Tiina Pirttimaki; David W Cope; H R Parri
Journal:  Eur J Neurosci       Date:  2011-03-13       Impact factor: 3.386

4.  Current and emerging treatments for absence seizures in young patients.

Authors:  Pascal Vrielynck
Journal:  Neuropsychiatr Dis Treat       Date:  2013-07-15       Impact factor: 2.570

Review 5.  Establishing Drug Effects on Electrocorticographic Activity in a Genetic Absence Epilepsy Model: Advances and Pitfalls.

Authors:  Gilles van Luijtelaar; Gerard van Oijen
Journal:  Front Pharmacol       Date:  2020-04-14       Impact factor: 5.810

6.  Stiripentol inhibits spike-and-wave discharges in animal models of absence seizures: A new mechanism of action involving T-type calcium channels.

Authors:  Veronique Riban; Isabelle Heulard; Lucie Reversat; Hakim Si Hocine; Marc Verleye
Journal:  Epilepsia       Date:  2022-03-09       Impact factor: 6.740
  6 in total

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