Literature DB >> 17641912

'Poppy seeds' in stomach aspirates: is oral omeprazole extemporaneous dispersion bioavailable?

Catherine Tuleu1, Sara Arenas-Lopez, Chris Robinson, David McCarthy, Richard I J Paget, Shane Tibby, Kevin M G Taylor.   

Abstract

We report the appearance of 'poppy seed'-like structures found in the aspirated stomach contents and faeces of a 3-month-old infant receiving an omeprazole liquid via nasogastric tube, prepared by dispersing an omeprazole tablet (10 mg MUPS(R)) in water. Electron microscopy and mass spectroscopy indicated that these particles were hollow, dark purple coloured spheres comprising undissolved omeprazole and its degradation products. These observations suggest rapid degradation of omeprazole in the acid stomach contents, with compromised absorption of active drug. Consequently, dispersion of omeprazole in water may be an inappropriate formulation in this setting.

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Year:  2007        PMID： 17641912     DOI： 10.1007/s00431-007-0567-z

Source DB:  PubMed          Journal:  Eur J Pediatr        ISSN： 0340-6199            Impact factor:   3.183


  2 in total

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2.  (Es)omeprazole and Discoloration of Regurgitated Gastric Contents in Infants: Worrying for Care-Takers and a Sign of a Reduced Bioavailability.

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