Literature DB >> 17641816

'Free' copper in serum of Alzheimer's disease patients correlates with markers of liver function.

R Squitti1, M Ventriglia, G Barbati, E Cassetta, F Ferreri, G Dal Forno, S Ramires, F Zappasodi, P M Rossini.   

Abstract

Non-ceruloplasmin bound copper ('free') seems slightly elevated in Alzheimer's disease (AD) patients. To test the hypothesis of a correlation between 'free' copper and liver function in AD. We evaluated 51 AD patients and 53 controls through typical tests for chronic liver disease (AST, ALT, gamma-GT, Albumin, prothrombin time - PT-, bilirubins), along with copper, ceruloplasmin, iron, cholesterol in the serum and apolipoprotein E epsilon4 (APOE4) genotype. Absolute serum copper and 'free' copper were higher, albumin was lower and PT longer in AD patients than in controls. 'Free' copper correlated negatively with markers of liver function, in that albumin and albumin/PT ratio (r = -0.43, p = 0.004), and positively with direct bilirubin. Copper and 'free' copper were higher in the APOE4 carriers. These results suggest that abnormalities in copper metabolism might have an effect on liver function in AD.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17641816     DOI： 10.1007/s00702-007-0777-6

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  41 in total

1.  Automated assay of ceruloplasmin by kinetic analysis of o-dianisidine oxidation.

Authors:  J D Boyett; H P Lehmann; M F Beeler
Journal:  Clin Chim Acta       Date:  1976-06-01       Impact factor: 3.786

2.  Standardization of serum ceruloplasmin concentrations in international enzyme units with o-dianisidine dihydrochloride as substrate.

Authors:  H P Lehmann; K H Schosinsky; M F Beeler
Journal:  Clin Chem       Date:  1974-12       Impact factor: 8.327

3.  Quantitative determination of serum triglycerides by the use of enzymes.

Authors:  G Bucolo; H David
Journal:  Clin Chem       Date:  1973-05       Impact factor: 8.327

4.  Measurement of ceruloplasmin from its oxidase activity in serum by use of o-dianisidine dihydrochloride.

Authors:  K H Schosinsky; H P Lehmann; M F Beeler
Journal:  Clin Chem       Date:  1974-12       Impact factor: 8.327

5.  New substrates for measuring gamma-glutamyl transpeptidase activity.

Authors:  G Szasz
Journal:  Z Klin Chem Klin Biochem       Date:  1974-05

6.  Serum zinc, copper, insulin and lipids in Alzheimer's disease epsilon 4 apolipoprotein E allele carriers.

Authors:  C González; T Martín; J Cacho; M T Breñas; T Arroyo; B García-Berrocal; J A Navajo; J M González-Buitrago
Journal:  Eur J Clin Invest       Date:  1999-07       Impact factor: 4.686

7.  Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts.

Authors:  Shayne A Bellingham; Giuseppe D Ciccotosto; B Elise Needham; Lisa R Fodero; Anthony R White; Colin L Masters; Roberto Cappai; James Camakaris
Journal:  J Neurochem       Date:  2004-10       Impact factor: 5.372

8.  Studies of cholecystokinin-stimulated biliary secretions reveal a high molecular weight copper-binding substance in normal subjects that is absent in patients with Wilson's disease.

Authors:  V Iyengar; G J Brewer; R D Dick; O Y Chung
Journal:  J Lab Clin Med       Date:  1988-03

9.  Apolipoprotein E polymorphism in Italy investigated in native plasma by a simple polyacrylamide gel isoelectric focusing technique. Comparison with frequency data of other European populations.

Authors:  R M Corbo; R Scacchi; L Mureddu; G Mulas; G Alfano
Journal:  Ann Hum Genet       Date:  1995-04       Impact factor: 1.670

10.  Proteome-based plasma biomarkers for Alzheimer's disease.

Authors:  A Hye; S Lynham; M Thambisetty; M Causevic; J Campbell; H L Byers; C Hooper; F Rijsdijk; S J Tabrizi; S Banner; C E Shaw; C Foy; M Poppe; N Archer; G Hamilton; J Powell; R G Brown; P Sham; M Ward; S Lovestone
Journal:  Brain       Date:  2006-11       Impact factor: 13.501
View more
  16 in total

1.  Abnormal clotting of the intrinsic/contact pathway in Alzheimer disease patients is related to cognitive ability.

Authors:  Georgette L Suidan; Pradeep K Singh; Sunita Patel-Hett; Zu-Lin Chen; Dmitri Volfson; Hitomi Yamamoto-Imoto; Erin H Norris; Robert D Bell; Sidney Strickland
Journal:  Blood Adv       Date:  2018-05-08

2.  Assessing candidate serum biomarkers for Alzheimer's disease: a longitudinal study.

Authors:  Matthew Zabel; Matthew Schrag; Claudius Mueller; Weidong Zhou; Andrew Crofton; Floyd Petersen; April Dickson; Wolff M Kirsch
Journal:  J Alzheimers Dis       Date:  2012       Impact factor: 4.472

3.  The elevated copper binding strength of amyloid-β aggregates allows the sequestration of copper from albumin: a pathway to accumulation of copper in senile plaques.

Authors:  Dianlu Jiang; Lin Zhang; Gian Paola G Grant; Christopher G Dudzik; Shu Chen; Sveti Patel; Yuanqiang Hao; Glenn L Millhauser; Feimeng Zhou
Journal:  Biochemistry       Date:  2013-01-11       Impact factor: 3.162

4.  ATP7B variants as modulators of copper dyshomeostasis in Alzheimer's disease.

Authors:  Rosanna Squitti; Renato Polimanti; Mariacristina Siotto; Serena Bucossi; Mariacarla Ventriglia; Stefania Mariani; Fabrizio Vernieri; Federica Scrascia; Laura Trotta; Paolo Maria Rossini
Journal:  Neuromolecular Med       Date:  2013-06-13       Impact factor: 3.843

5.  Implications of metal exposure and liver function in Parkinsonian patients resident in the vicinities of ferroalloy plants.

Authors:  Rosanna Squitti; G Gorgone; V Panetta; R Lucchini; S Bucossi; E Albini; L Alessio; A Alberici; J M Melgari; L Benussi; G Binetti; P M Rossini; F Draicchio
Journal:  J Neural Transm (Vienna)       Date:  2009-08-14       Impact factor: 3.575

6.  Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease.

Authors:  Ya Hui Hung; Elysia L Robb; Irene Volitakis; Michael Ho; Genevieve Evin; Qiao-Xin Li; Janetta G Culvenor; Colin L Masters; Robert A Cherny; Ashley I Bush
Journal:  J Biol Chem       Date:  2009-06-19       Impact factor: 5.157

7.  Copper phenotype in Alzheimer's disease: dissecting the pathway.

Authors:  Rosanna Squitti; Renato Polimanti
Journal:  Am J Neurodegener Dis       Date:  2013-06-21

8.  Ceruloplasmin fragmentation is implicated in 'free' copper deregulation of Alzheimer's disease.

Authors:  Rosanna Squitti; Carlo C Quattrocchi; Carlo Salustri; Paolo M Rossini
Journal:  Prion       Date:  2008-01-14       Impact factor: 3.931

9.  Association between the c. 2495 A>G ATP7B Polymorphism and Sporadic Alzheimer's Disease.

Authors:  Serena Bucossi; Stefania Mariani; Mariacarla Ventriglia; Renato Polimanti; Massimo Gennarelli; Cristian Bonvicini; Patrizio Pasqualetti; Federica Scrascia; Simone Migliore; Fabrizio Vernieri; Paolo M Rossini; Rosanna Squitti
Journal:  Int J Alzheimers Dis       Date:  2011-06-15

10.  Links between copper and cholesterol in Alzheimer's disease.

Authors:  Ya Hui Hung; Ashley I Bush; Sharon La Fontaine
Journal:  Front Physiol       Date:  2013-05-16       Impact factor: 4.566
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.