Current concepts of hypoxic-ischemic cerebral injury in the term newborn.

Acute perinatal hypoxic-ischemic cerebral injury in the term newborn is a major cause of long-term neurologic abnormalities in childhood. Earlier diagnosis and more precise localization of hypoxic-ischemic cerebral injury has been made possible by optimal timing and the use of new imaging modalities (e.g., magnetic resonance imaging, spectroscopy, computed tomography, cerebral perfusion techniques). Recent concepts on pathogenesis of such injury involves metabolic factors, regional distribution of excitatory (glutamate) synapses, and factors related to active myelination in specific areas at the time of insult. Consideration of these aspects of pathogenesis permit a rational approach to the management of this major neurologic problem in the newborn.