Literature DB >> 1764044

Identification of bile acid-CoA: amino acid N-acyltransferase in rat kidney.

J B Kwakye1, M R Johnson, S Barnes, W E Grizzle, R B Diasio.   

Abstract

A novel location of the bile-acid-conjugating enzyme bile acid-CoA:amino acid N-acyltransferase (BAT) has been discovered in the cytosolic fraction of rat kidney. Both taurine and glycine were utilized as substrates. Formation of bile acid N-acyl amidates was verified by h.p.l.c. by comparison with authentic standards and by specific hydrolysis using cholylglycine hydrolase. Immunoblot analysis using a human liver anti-BAT polyclonal antibody indicated that rat kidney BAT has the same molecular mass as rat liver BAT. These findings suggest that the kidney has a role in bile acid metabolism and physiology.

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Year:  1991        PMID： 1764044      PMCID： PMC1130530          DOI： 10.1042/bj2800821

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  13 in total

1.  RENAL EXCRETION OF BILE ACIDS: TAUROCHOLIC, GLYCOCHOLIC, AND COLIC ACIDS.

Authors:  I M WEINER; J E GLASSER; L LACK
Journal:  Am J Physiol       Date:  1964-11

2.  Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver.

Authors:  M R Johnson; S Barnes; J B Kwakye; R B Diasio
Journal:  J Biol Chem       Date:  1991-06-05       Impact factor: 5.157

3.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

4.  The role of tubular reabsorption in the renal excretion of bile acids.

Authors:  S Barnes; J L Gollan; B H Billing
Journal:  Biochem J       Date:  1977-07-15       Impact factor: 3.857

5.  Radioassay of bile acid coenzyme A:glycine/taurine: N-acyltransferase using an n-butanol solvent extraction procedure.

Authors:  M R Johnson; S Barnes; R B Diasio
Journal:  Anal Biochem       Date:  1989-11-01       Impact factor: 3.365

6.  2-Fluoro-beta-alanine, a previously unrecognized substrate for bile acid coenzyme A:amino acid:N-acyltransferase from human liver.

Authors:  M R Johnson; S Barnes; D J Sweeny; R B Diasio
Journal:  Biochem Pharmacol       Date:  1990-09-15       Impact factor: 5.858

7.  Relationship between the biliary excretion of bile acids and the excretion of water, lecithin, and cholesterol in man.

Authors:  T Scherstén; S Nilsson; E Cahlin; M Filipson; G Brodin-Persson
Journal:  Eur J Clin Invest       Date:  1971-01       Impact factor: 4.686

8.  Metabolism of 5-fluorouracil to an N-cholyl-2-fluoro-beta-alanine conjugate: previously unrecognized role for bile acids in drug conjugation.

Authors:  D J Sweeny; S Barnes; G D Heggie; R B Diasio
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

9.  The enzymatic cleavage of the carbon-nitrogen bond in 3-alpha, 7-alpha, 12-alpha-trihydroxy-5-beta-cholan-24-oylglycine.

Authors:  P P Nair; M Gordon; J Reback
Journal:  J Biol Chem       Date:  1967-01-10       Impact factor: 5.157

10.  Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from rat liver.

Authors:  P G Killenberg; J T Jordan
Journal:  J Biol Chem       Date:  1978-02-25       Impact factor: 5.157
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  2 in total

1.  27-Oxygenation of C27-sterols and 25-hydroxylation of vitamin D3 in kidney: cloning, structure and expression of pig kidney CYP27A.

Authors:  H Postlind; F Hosseinpour; M Norlin; K Wikvall
Journal:  Biochem J       Date:  2000-04-15       Impact factor: 3.857

2.  Reduced expression of kan-1 (encoding putative bile acid-CoA-amino acid N-acyltransferase) mRNA in livers of rats after partial hepatectomy and during sepsis.

Authors:  M Furutani; S Arii; H Higashitsuji; M Mise; M Fukumoto; S Takano; H Nakayama; M Imamura; J Fujita
Journal:  Biochem J       Date:  1995-10-01       Impact factor: 3.857
  2 in total

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