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Literature DB >> 17640025

Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.

Paul A Stocks¹, Patrick G Bray, Victoria E Barton, Mohammed Al-Helal, Michael Jones, Nuna C Araujo, Peter Gibbons, Stephen A Ward, Ruth H Hughes, Giancarlo A Biagini, Jill Davies, Richard Amewu, Amy E Mercer, Gemma Ellis, Paul M O'Neill.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 17640025 DOI： 10.1002/anie.200604697

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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36 in total

1. The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials.

Authors: Amy E Mercer; Ian M Copple; James L Maggs; Paul M O'Neill; B Kevin Park
Journal: J Biol Chem Date: 2010-11-08 Impact factor: 5.157

Review 2. Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria.

Authors: Richard T Eastman; David A Fidock
Journal: Nat Rev Microbiol Date: 2009-11-02 Impact factor: 60.633

3. Synthesis of Artemisinin-Estrogen Hybrids Highly Active against HCMV, P. falciparum, and Cervical and Breast Cancer.

Authors: Tony Fröhlich; Anita Kiss; János Wölfling; Erzsébet Mernyák; Ágnes E Kulmány; Renáta Minorics; István Zupkó; Maria Leidenberger; Oliver Friedrich; Barbara Kappes; Friedrich Hahn; Manfred Marschall; Gyula Schneider; Svetlana B Tsogoeva
Journal: ACS Med Chem Lett Date: 2018-10-19 Impact factor: 4.345

4. Ferrous iron-dependent delivery of therapeutic agents to the malaria parasite.

Authors: Sumit S Mahajan; Jiri Gut; Philip J Rosenthal; Adam R Renslo
Journal: Future Med Chem Date: 2012-12 Impact factor: 3.808

5. Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities.

Authors: Daniela Miranda; Rita Capela; Inês S Albuquerque; Patrícia Meireles; Isa Paiva; Fátima Nogueira; Richard Amewu; Jiri Gut; Philip J Rosenthal; Rudi Oliveira; Maria M Mota; Rui Moreira; Francesc Marti; Miguel Prudêncio; Paul M O'Neill; Francisca Lopes
Journal: ACS Med Chem Lett Date: 2013-12-20 Impact factor: 4.345

6. Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7.

Authors: Hanafy M Ismail; Victoria Barton; Matthew Phanchana; Sitthivut Charoensutthivarakul; Michael H L Wong; Janet Hemingway; Giancarlo A Biagini; Paul M O'Neill; Stephen A Ward
Journal: Proc Natl Acad Sci U S A Date: 2016-02-08 Impact factor: 11.205

Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.

1. The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials.

Review 2. Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria.

3. Synthesis of Artemisinin-Estrogen Hybrids Highly Active against HCMV, P. falciparum, and Cervical and Breast Cancer.

4. Ferrous iron-dependent delivery of therapeutic agents to the malaria parasite.

5. Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities.

6. Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7.

7. Synthesis of acridines by the [4 + 2] annulation of arynes and 2-aminoaryl ketones.

8. Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria.

9. Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency.

Review 10. Artemisinins: their growing importance in medicine.