Literature DB >> 17638516

Metabolon, Inc.

John Ryals1, Kay Lawton, Daniel Stevens, Michael Milburn.   

Abstract

Metabolon is an emerging technology company developing proprietary analytical methods and software for biomarker discovery using metabolomics. The company's aim is to measure all small molecules (<1500 Da) in a biological sample. These small-molecule compounds include biochemicals of cellular metabolism and xenobiotics from diet and environment. Our proprietary mLIMStrade mark system contains advanced metabolomic software and automated data-processing tools that use a variety of data-analysis and quality-control algorithms to convert raw mass-spectrometry data to identified, quantitated compounds. Metabolon's primary focus is a fee-for-service business that exploits this technology for pharmaceutical and biotechnology companies, with additional clients in the consumer goods, cosmetics and agricultural industries. Fee-for-service studies are often collaborations with groups that employ a variety of technologies for biomarker discovery. Metabolon's goal is to develop technology that will automatically analyze any sample for the small-molecule components present and become a standard technology for applications in health and related sciences.

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Year:  2007        PMID: 17638516     DOI: 10.2217/14622416.8.7.863

Source DB:  PubMed          Journal:  Pharmacogenomics        ISSN: 1462-2416            Impact factor:   2.533


  12 in total

1.  Cell-autonomous circadian clock of hepatocytes drives rhythms in transcription and polyamine synthesis.

Authors:  Ann Atwood; Robert DeConde; Susanna S Wang; Todd C Mockler; Jamal S M Sabir; Trey Ideker; Steve A Kay
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-31       Impact factor: 11.205

2.  Human urinary metabolomic profile of PPARalpha induced fatty acid beta-oxidation.

Authors:  Andrew D Patterson; Ondrej Slanar; Kristopher W Krausz; Fei Li; Constance C Höfer; Frantisek Perlík; Frank J Gonzalez; Jeffrey R Idle
Journal:  J Proteome Res       Date:  2009-09       Impact factor: 4.466

3.  Metabolomic analysis of pressure-overloaded and infarcted mouse hearts.

Authors:  Brian E Sansbury; Angelica M DeMartino; Zhengzhi Xie; Alan C Brooks; Robert E Brainard; Lewis J Watson; Andrew P DeFilippis; Timothy D Cummins; Matthew A Harbeson; Kenneth R Brittian; Sumanth D Prabhu; Aruni Bhatnagar; Steven P Jones; Bradford G Hill
Journal:  Circ Heart Fail       Date:  2014-04-24       Impact factor: 8.790

4.  Metabolomic profiles and childhood obesity.

Authors:  Wei Perng; Matthew W Gillman; Abby F Fleisch; Ryan D Michalek; Steven M Watkins; Elvira Isganaitis; Mary-Elizabeth Patti; Emily Oken
Journal:  Obesity (Silver Spring)       Date:  2014-09-24       Impact factor: 5.002

5.  A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos.

Authors:  Elena V Feofanova; Han Chen; Yulin Dai; Peilin Jia; Megan L Grove; Alanna C Morrison; Qibin Qi; Martha Daviglus; Jianwen Cai; Kari E North; Cathy C Laurie; Robert C Kaplan; Eric Boerwinkle; Bing Yu
Journal:  Am J Hum Genet       Date:  2020-10-07       Impact factor: 11.025

6.  The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism.

Authors:  Stephanos Pavlides; Aristotelis Tsirigos; Gemma Migneco; Diana Whitaker-Menezes; Barbara Chiavarina; Neal Flomenberg; Philippe G Frank; Mathew C Casimiro; Chenguang Wang; Richard G Pestell; Ubaldo E Martinez-Outschoorn; Anthony Howell; Federica Sotgia; Michael P Lisanti
Journal:  Cell Cycle       Date:  2010-09-01       Impact factor: 4.534

7.  Multiomics of World Trade Center Particulate Matter-induced Persistent Airway Hyperreactivity. Role of Receptor for Advanced Glycation End Products.

Authors:  Syed H Haider; Arul Veerappan; George Crowley; Erin J Caraher; Dean Ostrofsky; Mena Mikhail; Rachel Lam; Yuyan Wang; Maria Sunseri; Sophia Kwon; David J Prezant; Mengling Liu; Ann Marie Schmidt; Anna Nolan
Journal:  Am J Respir Cell Mol Biol       Date:  2020-08       Impact factor: 6.914

8.  In vivo commensal control of Clostridioides difficile virulence.

Authors:  Brintha P Girinathan; Nicholas DiBenedetto; Jay N Worley; Johann Peltier; Mario L Arrieta-Ortiz; Selva Rupa Christinal Immanuel; Richard Lavin; Mary L Delaney; Christopher K Cummins; Maria Hoffman; Yan Luo; Narjol Gonzalez-Escalona; Marc Allard; Andrew B Onderdonk; Georg K Gerber; Abraham L Sonenshein; Nitin S Baliga; Bruno Dupuy; Lynn Bry
Journal:  Cell Host Microbe       Date:  2021-10-11       Impact factor: 21.023

9.  Plasma metabolite profiles in children with current asthma.

Authors:  R S Kelly; J E Sordillo; J Lasky-Su; A Dahlin; W Perng; S L Rifas-Shiman; S T Weiss; D R Gold; A A Litonjua; M-F Hivert; E Oken; A C Wu
Journal:  Clin Exp Allergy       Date:  2018-07-03       Impact factor: 5.018

10.  PEDF, a pleiotropic WTC-LI biomarker: Machine learning biomarker identification and validation.

Authors:  George Crowley; James Kim; Sophia Kwon; Rachel Lam; David J Prezant; Mengling Liu; Anna Nolan
Journal:  PLoS Comput Biol       Date:  2021-07-21       Impact factor: 4.475

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