Stereochemistry of enacyloxins. Part 4: Complete structural and configurational assignment of the enacyloxin family, a series of antibiotics from Frateuria sp. W-315.

The absolute configurations of the enacyloxins, a series of polyhydroxylated polyene antibiotics from Frateuria species, were determined. The so far elusive (13'R,14'R,15'S)-configuration was assigned to enacycloxin IVa (1) by means of 'J-resolved HMBC-1' and NOESY NMR methods.