| Literature DB >> 17634904 |
Brian Walitt1, Tresa Roebuck-Spencer, Guiseppe Esposito, Frances Atkins, Joseph Bleiberg, Gregory Foster, Arthur Weinstein.
Abstract
Aberrant central neurological functioning is believed to contribute to the abnormal sensations of fibromyalgia (FM). This pilot study sought to determine if alterations in regional brain metabolism from baseline occur in FM after undergoing a multidisciplinary therapeutic regimen. Regional brain metabolic activity was estimated using (18)F-fluorodeoxyglucose positron emission tomography ((18)FDG PET). Nine participants with FM received an 8-week comprehensive treatment program. Serial testing with (18)FDG PET and the Fibromyalgia Impact Questionnaire were performed. Statistical analysis was performed using repeated Wilcoxon signed rank tests. A clinical improvement (FIQ median change 20.68, P = 0.005) was noted with treatment. With treatment, increases in brain metabolism were noted in various components of the limbic system (P = 0.004-0.1). An increase in limbic metabolism was noted with concomitant symptomatic improvement, suggesting that the limbic system attenuates FM symptoms.Entities:
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Year: 2007 PMID： 17634904 DOI： 10.1007/s00296-007-0405-7
Source DB: PubMed Journal: Rheumatol Int ISSN： 0172-8172 Impact factor: 2.631