A new method for x-ray scatter correction: first assessment on a cone-beam CT experimental setup.

Cone-beam computed tomography (CBCT) enables three-dimensional imaging with isotropic resolution and a shorter acquisition time compared to a helical CT scanner. Because a larger object volume is exposed for each projection, scatter levels are much higher than in collimated fan-beam systems, resulting in cupping artifacts, streaks and quantification inaccuracies. In this paper, a general method to correct for scatter in CBCT, without supplementary on-line acquisition, is presented. This method is based on scatter calibration through off-line acquisition combined with on-line analytical transformation based on physical equations, to adapt calibration to the object observed. The method was tested on a PMMA phantom and on an anthropomorphic thorax phantom. The results were validated by comparison to simulation for the PMMA phantom and by comparison to scans obtained on a commercial multi-slice CT scanner for the thorax phantom. Finally, the improvements achieved with the new method were compared to those obtained using a standard beam-stop method. The new method provided results that closely agreed with the simulation and with the conventional CT scanner, eliminating cupping artifacts and significantly improving quantification. Compared to the beam-stop method, lower x-ray doses and shorter acquisition times were needed, both divided by a factor of 9 for the same scatter estimation accuracy.