Literature DB >> 17634585

Methods of evaluating the effect of pharmacological drugs on aging and life span in mice.

Vladimir N Anisimov1, Irina G Popovich, Mark A Zabezhinski.   

Abstract

The methodology of testing anti-aging drugs in laboratory mice is presented. It includes the selection of mouse strain, sex, age at start of treatment, housing conditions, design of the long-term study, some noninvasive methods of assessment, pathology examination, and statistical treatment of the results.

Entities:  

Mesh：

Year:  2007        PMID： 17634585     DOI： 10.1007/978-1-59745-361-5_17

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  9 in total

1.  Exposure to light at night accelerates aging and spontaneous uterine carcinogenesis in female 129/Sv mice.

Authors:  Irina G Popovich; Mark A Zabezhinski; Andrei V Panchenko; Tatiana S Piskunova; Anna V Semenchenko; Maragriata L Tyndyk; Maria N Yurova; Vladimir N Anisimov
Journal:  Cell Cycle       Date:  2013-05-06       Impact factor: 4.534

Review 2.  The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer.

Authors:  Vladimir N Anisimov; Andrzej Bartke
Journal:  Crit Rev Oncol Hematol       Date:  2013-02-21       Impact factor: 6.312

3.  Rapamycin extends maximal lifespan in cancer-prone mice.

Authors:  Vladimir N Anisimov; Mark A Zabezhinski; Irina G Popovich; Tatiana S Piskunova; Anna V Semenchenko; Margarita L Tyndyk; Maria N Yurova; Marina P Antoch; Mikhail V Blagosklonny
Journal:  Am J Pathol       Date:  2010-04-02       Impact factor: 4.307

4.  Sex differences in aging, life span and spontaneous tumorigenesis in 129/Sv mice neonatally exposed to metformin.

Authors:  Vladimir N Anisimov; Irina G Popovich; Mark A Zabezhinski; Peter A Egormin; Maria N Yurova; Anna V Semenchenko; Margarita L Tyndyk; Andrey V Panchenko; Alexandr P Trashkov; Andrey G Vasiliev; Nikolai V Khaitsev
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

5.  Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice.

Authors:  Vladimir N Anisimov; Tatiana S Piskunova; Irina G Popovich; Mark A Zabezhinski; Margarita L Tyndyk; Peter A Egormin; Maria V Yurova; Svetlana V Rosenfeld; Anna V Semenchenko; Irina G Kovalenko; Tatiana E Poroshina; Lev M Berstein
Journal:  Aging (Albany NY)       Date:  2010-12       Impact factor: 5.682

Review 6.  Metformin for aging and cancer prevention.

Authors:  Vladimir N Anisimov
Journal:  Aging (Albany NY)       Date:  2010-11       Impact factor: 5.682

7.  If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.

Authors:  Vladimir N Anisimov; Lev M Berstein; Irina G Popovich; Mark A Zabezhinski; Peter A Egormin; Tatiana S Piskunova; Anna V Semenchenko; Margarita L Tyndyk; Maria N Yurova; Irina G Kovalenko; Tatiana E Poroshina
Journal:  Aging (Albany NY)       Date:  2011-02       Impact factor: 5.682

8.  Effects of the mitochondria-targeted antioxidant SkQ1 on lifespan of rodents.

Authors:  Vladimir N Anisimov; Maxim V Egorov; Marina S Krasilshchikova; Konstantin G Lyamzaev; Vasily N Manskikh; Mikhail P Moshkin; Evgeny A Novikov; Irina G Popovich; Konstantin A Rogovin; Irina G Shabalina; Olga N Shekarova; Maxim V Skulachev; Tatiana V Titova; Vladimir A Vygodin; Mikhail Yu Vyssokikh; Maria N Yurova; Mark A Zabezhinsky; Vladimir P Skulachev
Journal:  Aging (Albany NY)       Date:  2011-11       Impact factor: 5.682

9.  Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice.

Authors:  Tatiana S Piskunova; Maria N Yurova; Anton I Ovsyannikov; Anna V Semenchenko; Mark A Zabezhinski; Irina G Popovich; Zhao-Qi Wang; Vladimir N Anisimov
Journal:  Curr Gerontol Geriatr Res       Date:  2008-04-14
  9 in total

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