Literature DB >> 1763431

Chaos and illusion.

J M van Rossum1, J E de Bie.   

Abstract

Pharmacology is the study of the interaction of drugs with living organisms, especially humans. The body is a very complicated system, which suggests that the 'effect' induced by a drug is not a single entity but a change in several variables at the same time, all of which are interrelated in a nonlinear fashion. Research on nonlinear systems in other fields of science--commonly known as chaos theory--may therefore be of use in understanding pharmacology, as explained here by J. M. van Rossum and J. E. G. M. de Bie. They argue that in the study of drug effects, several variables should be measured simultaneously. Many pharmacologists prefer to construct an illusion of reality, studying just one of the essential variables and averaging data in a population of subjects, thus losing the opportunity to understand what a drug really does to a patient.

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Year:  1991        PMID: 1763431     DOI: 10.1016/0165-6147(91)90608-u

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN: 0165-6147            Impact factor:   14.819


  5 in total

Review 1.  Nonlinear dynamics and chaos theory: concepts and applications relevant to pharmacodynamics.

Authors:  A Dokoumetzidis; A Iliadis; P Macheras
Journal:  Pharm Res       Date:  2001-04       Impact factor: 4.200

Review 2.  Nonlinear dynamics in clinical pharmacology: the paradigm of cortisol secretion and suppression.

Authors:  Aristides Dokoumetzidis; Athanassios Iliadis; Panos Macheras
Journal:  Br J Clin Pharmacol       Date:  2002-07       Impact factor: 4.335

Review 3.  Fractal geometry, fractal kinetics and chaos en route to biopharmaceutical sciences.

Authors:  P Macheras; P Argyrakis; C Polymilis
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1996 Apr-Jun       Impact factor: 2.441

4.  Estimating parameters of nonlinear dynamic systems in pharmacology using chaos synchronization and grid search.

Authors:  Nikhil Pillai; Sorell L Schwartz; Thang Ho; Aris Dokoumetzidis; Robert Bies; Immanuel Freedman
Journal:  J Pharmacokinet Pharmacodyn       Date:  2019-03-30       Impact factor: 2.745

5.  Immunology and homeopathy. 5. The rationale of the 'Simile'.

Authors:  Paolo Bellavite; Riccardo Ortolani; Francesco Pontarollo; Giuseppina Pitari; Anita Conforti
Journal:  Evid Based Complement Alternat Med       Date:  2007-02-05       Impact factor: 2.629

  5 in total

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