OBJECTIVE: To determine the association between pancreatic cancer and medical conditions. METHODS:A large population-based case-control study identified pancreatic cancer cases in the San Francisco Bay Area between 1995 and 1999. A total of 1,701 controls were randomly selected from the same population and were frequency-matched to 532 cases by sex and age. In-person interviews were conducted with no proxy interviews. RESULTS: Prior history of gallbladder disease was associated with increased risk of pancreatic cancer (OR = 1.6, 95% CI = 1.2-2.2), with the highest risk occurring for gallbladder disease not caused by cholelithiasis (OR = 2.1, 95% CI = 1.1-3.7). Risk was associated with cholelithiasis only for participants diagnosed within the year before their pancreatic cancer (OR = 15, 95% CI = 6.2-34), and for those with cholelithiasis and cholecystectomy within the same time frame (OR = 28, 95% CI = 8.2-96). Gastric and/or duodenal ulcers were associated with increased risk of pancreatic cancer for individuals with ulcers of <or=two years duration (OR = 2.3, 95% CI = 1.1-4.6). Hyperthyroidism (OR = 2.1, 95% CI = 1.0-4.2) and "other" thyroid conditions (OR = 2.2, 95% CI = 1.1-4.2) were associated with increased risk. Participants with at least one first-degree relative with pancreatic cancer had an increased risk (OR = 1.6, 95% CI = 1.1-2.5). CONCLUSION: History of recent gallbladder conditions, gastric and/or duodenal ulcers may represent an early manifestation of pancreatic cancer rather than an independent risk factor. These results warrant further investigation in pooled analyses.
RCT Entities:
OBJECTIVE: To determine the association between pancreatic cancer and medical conditions. METHODS: A large population-based case-control study identified pancreatic cancer cases in the San Francisco Bay Area between 1995 and 1999. A total of 1,701 controls were randomly selected from the same population and were frequency-matched to 532 cases by sex and age. In-person interviews were conducted with no proxy interviews. RESULTS: Prior history of gallbladder disease was associated with increased risk of pancreatic cancer (OR = 1.6, 95% CI = 1.2-2.2), with the highest risk occurring for gallbladder disease not caused by cholelithiasis (OR = 2.1, 95% CI = 1.1-3.7). Risk was associated with cholelithiasis only for participants diagnosed within the year before their pancreatic cancer (OR = 15, 95% CI = 6.2-34), and for those with cholelithiasis and cholecystectomy within the same time frame (OR = 28, 95% CI = 8.2-96). Gastric and/or duodenal ulcers were associated with increased risk of pancreatic cancer for individuals with ulcers of <or=two years duration (OR = 2.3, 95% CI = 1.1-4.6). Hyperthyroidism (OR = 2.1, 95% CI = 1.0-4.2) and "other" thyroid conditions (OR = 2.2, 95% CI = 1.1-4.2) were associated with increased risk. Participants with at least one first-degree relative with pancreatic cancer had an increased risk (OR = 1.6, 95% CI = 1.1-2.5). CONCLUSION: History of recent gallbladder conditions, gastric and/or duodenal ulcers may represent an early manifestation of pancreatic cancer rather than an independent risk factor. These results warrant further investigation in pooled analyses.
Authors: Leticia Nogueira; Neal D Freedman; Eric A Engels; Joan L Warren; Felipe Castro; Jill Koshiol Journal: Am J Epidemiol Date: 2014-01-26 Impact factor: 4.897
Authors: H A Sterle; M L Barreiro Arcos; E Valli; M A Paulazo; S P Méndez Huergo; A G Blidner; F Cayrol; M C Díaz Flaqué; A J Klecha; V A Medina; L Colombo; G A Rabinovich; G A Cremaschi Journal: J Mol Med (Berl) Date: 2015-11-13 Impact factor: 4.599
Authors: C Bosetti; E Lucenteforte; P M Bracci; E Negri; R E Neale; H A Risch; S H Olson; S Gallinger; A B Miller; H B Bueno-de-Mesquita; R Talamini; J Polesel; P Ghadirian; P A Baghurst; W Zatonski; E Fontham; E A Holly; Y T Gao; H Yu; R C Kurtz; M Cotterchio; P Maisonneuve; M P Zeegers; E J Duell; P Boffetta; C La Vecchia Journal: Ann Oncol Date: 2013-08-22 Impact factor: 32.976
Authors: P Eijgenraam; M M Heinen; B A J Verhage; Y C Keulemans; L J Schouten; P A van den Brandt Journal: Br J Cancer Date: 2013-10-22 Impact factor: 7.640