BACKGROUND: The presence of biliary obstruction in patients with gallbladder cancer (GBC) is generally viewed as an indicator of advanced disease, inoperability and poor prognosis. METHODS: Data was collected from patients with GBC with obstructive jaundice who underwent resection during the period January 2001 to October 2003. Systematic analysis of prospective data was undertaken; patients were analyzed for resectability, post-operative morbidity, mortality and disease-free survival. RESULTS: During this period 14 patients with GBC with biliary obstruction underwent resection with curative intent. In these jaundiced patients, the resectability rate was 27.45% (14 of 51). In the jaundiced group the mortality was 7.14% the morbidity rate 50%, the mean disease free survival was 23.46 months (median 26 months and range of 2 to 62 months). Seven patients (50%) survived more than two years. CONCLUSION: Biliary obstruction in gall bladder cancer is not sine qua non of inoperability and resection results in meaningful prolongation of survival.
BACKGROUND: The presence of biliary obstruction in patients with gallbladder cancer (GBC) is generally viewed as an indicator of advanced disease, inoperability and poor prognosis. METHODS: Data was collected from patients with GBC with obstructive jaundice who underwent resection during the period January 2001 to October 2003. Systematic analysis of prospective data was undertaken; patients were analyzed for resectability, post-operative morbidity, mortality and disease-free survival. RESULTS: During this period 14 patients with GBC with biliary obstruction underwent resection with curative intent. In these jaundicedpatients, the resectability rate was 27.45% (14 of 51). In the jaundiced group the mortality was 7.14% the morbidity rate 50%, the mean disease free survival was 23.46 months (median 26 months and range of 2 to 62 months). Seven patients (50%) survived more than two years. CONCLUSION:Biliary obstruction in gall bladder cancer is not sine qua non of inoperability and resection results in meaningful prolongation of survival.
Authors: O I Alatise; O O Lawal; A O Adisa; O A Arowolo; O O Ayoola; E A Agbakwuru; A R K Adesunkanmi; G O Omoniyi-Esan; O O Olaofe Journal: J Gastrointest Cancer Date: 2012-09
Authors: Thuy B Tran; Jeffrey A Norton; Cecilia G Ethun; Timothy M Pawlik; Stefan Buettner; Carl Schmidt; Eliza W Beal; William G Hawkins; Ryan C Fields; Bradley A Krasnick; Sharon M Weber; Ahmed Salem; Robert C G Martin; Charles R Scoggins; Perry Shen; Harveshp D Mogal; Kamran Idrees; Chelsea A Isom; Ioannis Hatzaras; Rivfka Shenoy; Shishir K Maithel; George A Poultsides Journal: J Gastrointest Surg Date: 2017-05-11 Impact factor: 3.452