| Literature DB >> 17632082 |
Anissa Chikh1, Emre Sayan, Sebastien Thibaut, Anna Maria Lena, Sabrina DiGiorgi, Bruno A Bernard, Gerry Melino, Eleonora Candi.
Abstract
The epidermis is a multi-layered stratified epithelium continuously renewed by differentiating keratinocytes that develops by the action of p63, a member of the p53 family. The TP63 contains two promoters, resulting in the expression of different proteins, containing (TAp63) or not (DeltaNp63) an amino-terminal transactivation domain, which contribution in skin formation is not fully understood. We found that p63 binds and transactivate GATA-3 promoter, which in turn transactivate IKKalpha, two pivotal regulators of epithelial development. Indeed, GATA-3 is a regulator of cell lineage in skin and hair follicles formation. To further study the relationship between GATA-3 and p63 isoforms here we investigated their expression during keratinocyte differentiation, in human epidermis and hair follicle.Entities:
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Year: 2007 PMID： 17632082 DOI： 10.1016/j.bbrc.2007.06.069
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575