BACKGROUND: Few population-based studies have examined the whole range of subthreshold syndromes and disorders of anxiety and depression in older people. AIMS: To investigate the co-occurrence of anxiety and depressive syndromes in older people. Associations between these conditions and personal and environmental factors are examined. METHOD: MRC CFAS included 13,004, age 65 years and above, who completed the initial screening interview. A stratified random subsample of 2,640 participated in the assessment interview where the Geriatric Mental State Examination (GMS) was administered. The AGECAT diagnostic system was used to generate subthreshold and disorder-level of anxiety and depression as well as the combination of these into eight syndromes categories plus a group without any of the syndromes categories. Prevalences, unadjusted and adjusted odds ratios are calculated for the syndrome categories in relation to cross-sectional personal and environmental factors, and odds ratios of subthreshold and disorders level are estimated. RESULTS: The overall prevalence of anxiety and depressive disorders are 3.1% and 9.7% respectively. The overall prevalence of either anxiety or depressive disorder (anxiety disorder with subthreshold depression, mixed anxiety and depressive disorder with subthreshold anxiety) where they overlapped is 8.4%. The highest Odds Ratios unadjusted and adjusted for age and gender, of anxiety and depressive disorders and significant for trend are found for increasing disability. Disability has a strong relationship with all the co-morbid syndrome categories. In all analyses women showed significant higher estimates than men. CONCLUSIONS: Our study demonstrated high estimates where anxiety and depression occurred in parallel both as disorders and as subthreshold syndromes.
BACKGROUND: Few population-based studies have examined the whole range of subthreshold syndromes and disorders of anxiety and depression in older people. AIMS: To investigate the co-occurrence of anxiety and depressive syndromes in older people. Associations between these conditions and personal and environmental factors are examined. METHOD: MRC CFAS included 13,004, age 65 years and above, who completed the initial screening interview. A stratified random subsample of 2,640 participated in the assessment interview where the Geriatric Mental State Examination (GMS) was administered. The AGECAT diagnostic system was used to generate subthreshold and disorder-level of anxiety and depression as well as the combination of these into eight syndromes categories plus a group without any of the syndromes categories. Prevalences, unadjusted and adjusted odds ratios are calculated for the syndrome categories in relation to cross-sectional personal and environmental factors, and odds ratios of subthreshold and disorders level are estimated. RESULTS: The overall prevalence of anxiety and depressive disorders are 3.1% and 9.7% respectively. The overall prevalence of either anxiety or depressive disorder (anxiety disorder with subthreshold depression, mixed anxiety and depressive disorder with subthreshold anxiety) where they overlapped is 8.4%. The highest Odds Ratios unadjusted and adjusted for age and gender, of anxiety and depressive disorders and significant for trend are found for increasing disability. Disability has a strong relationship with all the co-morbid syndrome categories. In all analyses women showed significant higher estimates than men. CONCLUSIONS: Our study demonstrated high estimates where anxiety and depression occurred in parallel both as disorders and as subthreshold syndromes.
Authors: Sophie E Holmes; Irina Esterlis; Carolyn M Mazure; Yen Ying Lim; David Ames; Stephanie Rainey-Smith; Chris Fowler; Kathryn Ellis; Ralph N Martins; Olivier Salvado; Vincent Doré; Victor L Villemagne; Christopher C Rowe; Simon M Laws; Colin L Masters; Robert H Pietrzak; Paul Maruff Journal: Int J Geriatr Psychiatry Date: 2017-07-24 Impact factor: 3.485
Authors: J W Kasckow; J F Karp; E Whyte; M Butters; C Brown; A Begley; S Bensasi; C F Reynolds Journal: J Psychiatr Res Date: 2013-02-13 Impact factor: 4.791
Authors: Vonetta M Dotson; Sarah M Szymkowicz; Joshua W Kirton; Molly E McLaren; Mackenzie L Green; Jessica Y Rohani Journal: J Depress Anxiety Date: 2014-01-24
Authors: Molly E McLaren; Sarah M Szymkowicz; Andrew O'Shea; Adam J Woods; Stephen D Anton; Vonetta M Dotson Journal: Psychiatry Res Neuroimaging Date: 2016-12-16 Impact factor: 2.376
Authors: Karin Hek; Henning Tiemeier; Rachel S Newson; Hendrika J Luijendijk; Albert Hofman; Cornelis L Mulder Journal: Int J Methods Psychiatr Res Date: 2011-09 Impact factor: 4.035