OBJECTIVES: The imbalance in oxidative status together with nutrition depletion and low body weight play a vital role in the pathogenesis and severity of chronic obstructive pulmonary disease (COPD). The study was undertaken to ascertain if a relationship existed between oxidative status and BMI in COPD. In addition, association of oxidative status and BMI with lung function of the disease was also examined. MATERIALS AND METHODS: In 202 COPD patients and 136 healthy controls plasma lipid peroxidation (LPO), reduced glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT) activities, BMI and FEV(1)% predicted were looked for interactions. RESULTS: The patients had increased LPO (p=0.006) and decreased antioxidants (GSH, p=0.005; GPx, p=0.035 and CAT, p=0.008, respectively). Of note are the correlations of oxidative stress markers with BMI and FEV(1)% predicted in the patients. LPO inversely and GSH, GPx, and CAT positively correlated with both BMI (p=0.007, p<0.001, p=0.045 and p=0.009, respectively), and FEV(1)% of predicted (LPO, p=0.001; GSH, p<0.001; GPx, p=0.043 and CAT, p<0.001) in the patients. Further, a positive correlation existed between BMI and FEV(1)% predicted (p=0.016) in COPD. CONCLUSION: The intimate relationship of oxidative status with BMI and lung function, and the direct correlation between BMI and FEV(1) may potentiate severity of the disease.
OBJECTIVES: The imbalance in oxidative status together with nutrition depletion and low body weight play a vital role in the pathogenesis and severity of chronic obstructive pulmonary disease (COPD). The study was undertaken to ascertain if a relationship existed between oxidative status and BMI in COPD. In addition, association of oxidative status and BMI with lung function of the disease was also examined. MATERIALS AND METHODS: In 202 COPDpatients and 136 healthy controls plasma lipid peroxidation (LPO), reduced glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT) activities, BMI and FEV(1)% predicted were looked for interactions. RESULTS: The patients had increased LPO (p=0.006) and decreased antioxidants (GSH, p=0.005; GPx, p=0.035 and CAT, p=0.008, respectively). Of note are the correlations of oxidative stress markers with BMI and FEV(1)% predicted in the patients. LPO inversely and GSH, GPx, and CAT positively correlated with both BMI (p=0.007, p<0.001, p=0.045 and p=0.009, respectively), and FEV(1)% of predicted (LPO, p=0.001; GSH, p<0.001; GPx, p=0.043 and CAT, p<0.001) in the patients. Further, a positive correlation existed between BMI and FEV(1)% predicted (p=0.016) in COPD. CONCLUSION: The intimate relationship of oxidative status with BMI and lung function, and the direct correlation between BMI and FEV(1) may potentiate severity of the disease.
Authors: Meredith C McCormack; Andrew J Belli; Deepak A Kaji; Elizabeth C Matsui; Emily P Brigham; Roger D Peng; Cortlandt Sellers; D'Ann L Williams; Gregory B Diette; Patrick N Breysse; Nadia N Hansel Journal: Eur Respir J Date: 2015-01-08 Impact factor: 16.671
Authors: Biswajit Chakrabarti; Sabita Purkait; Punyabrata Gun; Vicky C Moore; Samadrita Choudhuri; M J Zaman; Christopher J Warburton; Peter M A Calverley; Rahul Mukherjee Journal: Int J Chron Obstruct Pulmon Dis Date: 2011-10-18
Authors: Terence A R Seemungal; Johanna Cho Fook Lun; Gershwin Davis; Carlos Neblett; Nkhabe Chinyepi; Christina Dookhan; Samantha Drakes; Elizabeth Mandeville; Fatima Nana; Seatshogeng Setlhake; Celia Poon King; Lexley Pinto Pereira; Lexley PintoPereira; Jerome Delisle; Thomas M A Wilkinson; Jagwiga A Wedzicha Journal: Int J Chron Obstruct Pulmon Dis Date: 2007