Literature DB >> 17630905

Induction of cytochrome P4502B: role of regulatory elements and nuclear receptors.

V O Pustylnyak1, L F Gulyaeva, V V Lyakhovich.   

Abstract

Cytochrome P450 of the 2B subfamily is easily induced by many xenobiotics. In spite of intensive investigations, the molecular mechanisms of regulation of the CYP2B genes are not clear. The nuclear receptor CAR is shown to play a crucial role in the activation of CYP2B genes by xenobiotics, but many problems of CAR activation in different animal species and humans remain unsolved. This review focuses on signaling pathways involved in the control of CYP2B gene expression in mammals.

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Year:  2007        PMID： 17630905     DOI： 10.1134/s000629790706003x

Source DB:  PubMed          Journal:  Biochemistry (Mosc)        ISSN： 0006-2979            Impact factor:   2.487


  4 in total

1.  Bioinformatic analysis of microRNA networks following the activation of the constitutive androstane receptor (CAR) in mouse liver.

Authors:  Ruixin Hao; Shengzhong Su; Yinan Wan; Frank Shen; Ben Niu; Denise M Coslo; Istvan Albert; Xing Han; Curtis J Omiecinski
Journal:  Biochim Biophys Acta       Date:  2016-04-11

2.  The constitutive androstane receptor activator 4-[(4R,6R)-4,6-diphenyl-1,3-dioxan-2-yl]-N,N-dimethylaniline inhibits the gluconeogenic genes PEPCK and G6Pase through the suppression of HNF4α and FOXO1 transcriptional activity.

Authors:  A A Yarushkin; E M Kachaylo; V O Pustylnyak
Journal:  Br J Pharmacol       Date:  2013-04       Impact factor: 8.739

3.  Toxicogenomic biomarkers for liver toxicity.

Authors:  Naoki Kiyosawa; Yosuke Ando; Sunao Manabe; Takashi Yamoto
Journal:  J Toxicol Pathol       Date:  2009-04-06       Impact factor: 1.628

4.  Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT.

Authors:  Naoki Kiyosawa; Joshua C Kwekel; Lyle D Burgoon; Edward Dere; Kurt J Williams; Colleen Tashiro; Brock Chittim; Timothy R Zacharewski
Journal:  BMC Genomics       Date:  2008-10-16       Impact factor: 3.969
  4 in total

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