Literature DB >> 17630753

19-epi-okadaic acid, a novel protein phosphatase inhibitor with enhanced selectivity.

Patricia G Cruz1, Antonio Hernández Daranas, José J Fernández, Manuel Norte.   

Abstract

A new protein phosphatase inhibitor, 19-epi-okadaic acid, was isolated from the marine dinoflagellate Prorocentrum belizeanum. Its structure and conformation in solution has been determined, and important differences were found when compared with the lead compound okadaic acid. The new metabolite showed nanomolar activities, and its selectivity for PP2A versus PP1 surpasses that shown by okadaic acid 10-fold, making it one of the most selective inhibitors of this class.

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Year:  2007        PMID： 17630753     DOI： 10.1021/ol071099i

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

1.  Structure-Activity Relationship Studies Using Natural and Synthetic Okadaic Acid/Dinophysistoxin Toxins.

Authors:  Michael J Twiner; Gregory J Doucette; Yucheng Pang; Chao Fang; Craig J Forsyth; Christopher O Miles
Journal:  Mar Drugs       Date:  2016-11-04       Impact factor: 5.118

2.  On the Mechanism of Action of Dragmacidins I and J, Two New Representatives of a New Class of Protein Phosphatase 1 and 2A Inhibitors.

Authors:  Patricia G Cruz; Juan Fernando Martínez Leal; Antonio Hernández Daranas; Marta Pérez; Carmen Cuevas
Journal:  ACS Omega       Date:  2018-04-03

Review 3.  Marine pharmacology in 2007-8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous system, and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Roberto G S Berlinck; Nobuhiro Fusetani
Journal:  Comp Biochem Physiol C Toxicol Pharmacol       Date:  2010-09-15       Impact factor: 3.228

4.  Dihydrodinophysistoxin-1 Produced by Dinophysis norvegica in the Gulf of Maine, USA and Its Accumulation in Shellfish.

Authors:  Jonathan R Deeds; Whitney L Stutts; Mary Dawn Celiz; Jill MacLeod; Amy E Hamilton; Bryant J Lewis; David W Miller; Kohl Kanwit; Juliette L Smith; David M Kulis; Pearse McCarron; Carlton D Rauschenberg; Craig A Burnell; Stephen D Archer; Jerry Borchert; Shelley K Lankford
Journal:  Toxins (Basel)       Date:  2020-08-20       Impact factor: 4.546

5.  Identification of 24-O-β-d-Glycosides and 7-Deoxy-Analogues of Okadaic Acid and Dinophysistoxin-1 and -2 in Extracts from Dinophysis Blooms, Dinophysis and Prorocentrum Cultures, and Shellfish in Europe, North America and Australasia.

Authors:  Alistair L Wilkins; Thomas Rundberget; Morten Sandvik; Frode Rise; Brent K Knudsen; Jane Kilcoyne; Beatriz Reguera; Pilar Rial; Elliott J Wright; Sabrina D Giddings; Michael J Boundy; Cheryl Rafuse; Christopher O Miles
Journal:  Toxins (Basel)       Date:  2021-07-21       Impact factor: 4.546

6.  Identification of 19-epi-okadaic acid, a new diarrhetic shellfish poisoning toxin, by liquid chromatography with mass spectrometry detection.

Authors:  Beatriz Paz; Antonio H Daranas; Patricia G Cruz; José M Franco; Manuel Norte; José J Fernández
Journal:  Mar Drugs       Date:  2008-08-28       Impact factor: 5.118

7.  Self-association of okadaic acid: structural and pharmacological significance.

Authors:  Patricia G Cruz; Manuel Norte; Alberto Hernández Creus; José J Fernández; Antonio Hernández Daranas
Journal:  Mar Drugs       Date:  2013-05-29       Impact factor: 5.118
  7 in total

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