Steven D Pinkerton1. 1. Center for AIDS Intervention Research, Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, 2071 North Summit Avenue, Milwaukee, WI 53202, USA. pinkrton@mcw.edu
Abstract
OBJECTIVE: To estimate the number of persons in the USA who acquire HIV as a consequence of risky sexual activities with an acutely-infected sex partner. METHODS: Estimates of the number of incident infections in the USA that are due to acute-phase HIV transmission were derived from a simple mathematical model that combined epidemiological data with information regarding the relative transmission rates for acutely-infected, nonacutely infected but serostatus-unaware, and serostatus-aware persons living with HIV. RESULTS: Approximately 2760 (8.6%) of the estimated 32 000 sexually-acquired HIV infections in the USA each year are due to acute-phase transmission of the virus. Multivariate sensitivity analyses with a liberal range of values for key parameters produced an upper bound of 5537 infections, representing 17.3% of the total number of sexually-acquired infections. CONCLUSIONS: Acute-phase HIV transmission accounts for fewer sexually-acquired infections in the USA than is generally assumed.
OBJECTIVE: To estimate the number of persons in the USA who acquire HIV as a consequence of risky sexual activities with an acutely-infected sex partner. METHODS: Estimates of the number of incident infections in the USA that are due to acute-phase HIV transmission were derived from a simple mathematical model that combined epidemiological data with information regarding the relative transmission rates for acutely-infected, nonacutely infected but serostatus-unaware, and serostatus-aware persons living with HIV. RESULTS: Approximately 2760 (8.6%) of the estimated 32 000 sexually-acquired HIV infections in the USA each year are due to acute-phase transmission of the virus. Multivariate sensitivity analyses with a liberal range of values for key parameters produced an upper bound of 5537 infections, representing 17.3% of the total number of sexually-acquired infections. CONCLUSIONS: Acute-phase HIV transmission accounts for fewer sexually-acquired infections in the USA than is generally assumed.
Authors: J S Koopman; J A Jacquez; G W Welch; C P Simon; B Foxman; S M Pollock; D Barth-Jones; A L Adams; K Lange Journal: J Acquir Immune Defic Syndr Hum Retrovirol Date: 1997-03-01
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