OBJECTIVE: Retinol-binding protein (RBP)-4 was recently identified as an adipokine that induces insulin resistance. In the current study, we investigated RBP-4 serum levels in diabetic and nondiabetic patients on chronic hemodialysis (CD) compared with control subjects with a glomerular filtration rate >50 ml/min. The majority of the diabetic subjects used oral hypoglycemic agents or insulin. RESEARCH DESIGN AND METHODS: RBP-4 was determined by enzyme-linked immunosorbent assay in control subjects (n = 59) and CD patients (n = 58) and correlated with clinical and biochemical measures of renal function, glucose and lipid metabolism, and inflammation in both groups. RESULTS: Mean serum RBP-4 levels were almost fourfold higher in CD patients (102 +/- 30 mg/l) compared with control subjects (28 +/- 8 mg/l). Furthermore, serum creatinine independently predicted RBP-4 concentrations in multiple regression analyses in both control subjects and CD patients. In addition, C-reactive protein and systolic blood pressure independently and negatively correlated with RBP-4 serum concentrations in CD patients but not control subjects. In contrast, markers of glucose and lipid metabolism were not independently related to serum RBP-4 in control subjects or CD patients. CONCLUSIONS: We show that markers of renal function are independently related to serum RBP-4 levels.
OBJECTIVE:Retinol-binding protein (RBP)-4 was recently identified as an adipokine that induces insulin resistance. In the current study, we investigated RBP-4 serum levels in diabetic and nondiabeticpatients on chronic hemodialysis (CD) compared with control subjects with a glomerular filtration rate >50 ml/min. The majority of the diabetic subjects used oral hypoglycemic agents or insulin. RESEARCH DESIGN AND METHODS: RBP-4 was determined by enzyme-linked immunosorbent assay in control subjects (n = 59) and CDpatients (n = 58) and correlated with clinical and biochemical measures of renal function, glucose and lipid metabolism, and inflammation in both groups. RESULTS: Mean serum RBP-4 levels were almost fourfold higher in CDpatients (102 +/- 30 mg/l) compared with control subjects (28 +/- 8 mg/l). Furthermore, serum creatinine independently predicted RBP-4 concentrations in multiple regression analyses in both control subjects and CDpatients. In addition, C-reactive protein and systolic blood pressure independently and negatively correlated with RBP-4 serum concentrations in CDpatients but not control subjects. In contrast, markers of glucose and lipid metabolism were not independently related to serum RBP-4 in control subjects or CDpatients. CONCLUSIONS: We show that markers of renal function are independently related to serum RBP-4 levels.
Authors: Qin Yang; Iratxe Eskurza; Urban A Kiernan; David A Phillips; Matthias Blüher; Timothy E Graham; Barbara B Kahn Journal: Endocrinology Date: 2012-01-17 Impact factor: 4.736
Authors: Alessio Molfino; Steven B Heymsfield; Fansan Zhu; Peter Kotanko; Nathan W Levin; Tjien Dwyer; George A Kaysen Journal: J Ren Nutr Date: 2013-04-24 Impact factor: 3.655
Authors: H Stepan; A Philipp; I Roth; S Kralisch; A Jank; W Schaarschmidt; U Lössner; J Kratzsch; M Blüher; M Stumvoll; M Fasshauer Journal: J Endocrinol Invest Date: 2011-07-27 Impact factor: 4.256