OBJECTIVE: To estimate the prevalence of an elevated albumin-to-creatinine ratio (ACR) (> or = 30 microg/mg) among youth with type 1 or type 2 diabetes and to identify factors associated with elevated ACR and their effect on the relationship between elevated ACR and type of diabetes. RESEARCH DESIGN AND METHODS: Cross-sectional data were analyzed from 3,259 participants with onset of diabetes at < 20 years of age in the SEARCH for Diabetes in Youth, a multicenter observational study of diabetes in youth. Multiple logistic regression was used to explore determinants of elevated ACR and factors accounting for differences in this prevalence between type 2 and type 1 diabetes. RESULTS: The prevalence of elevated ACR was 9.2% in type 1 and 22.2% in type 2 diabetes (prevalence ratio 2.4 [95% CI 1.9-3.0]; P < 0.0001). In multiple logistic regression analysis, female sex, A1C and triglyceride values, hypertension, and type of diabetes (type 2 versus type 1) were significantly associated with elevated ACR. Adjustment for variables related to insulin resistance (obesity, hypertension, dyslipidemia, and inflammation) attenuated, but did not completely explain, the association of diabetes type with elevated ACR. CONCLUSIONS: Youth with type 2 diabetes have a higher prevalence of elevated ACR than youth with type 1 diabetes, in an association that apparently does not completely depend on age, duration of diabetes, race/ethnicity, sex, level of glycemic control, or features of insulin resistance.
OBJECTIVE: To estimate the prevalence of an elevated albumin-to-creatinine ratio (ACR) (> or = 30 microg/mg) among youth with type 1 or type 2 diabetes and to identify factors associated with elevated ACR and their effect on the relationship between elevated ACR and type of diabetes. RESEARCH DESIGN AND METHODS: Cross-sectional data were analyzed from 3,259 participants with onset of diabetes at < 20 years of age in the SEARCH for Diabetes in Youth, a multicenter observational study of diabetes in youth. Multiple logistic regression was used to explore determinants of elevated ACR and factors accounting for differences in this prevalence between type 2 and type 1 diabetes. RESULTS: The prevalence of elevated ACR was 9.2% in type 1 and 22.2% in type 2 diabetes (prevalence ratio 2.4 [95% CI 1.9-3.0]; P < 0.0001). In multiple logistic regression analysis, female sex, A1C and triglyceride values, hypertension, and type of diabetes (type 2 versus type 1) were significantly associated with elevated ACR. Adjustment for variables related to insulin resistance (obesity, hypertension, dyslipidemia, and inflammation) attenuated, but did not completely explain, the association of diabetes type with elevated ACR. CONCLUSIONS: Youth with type 2 diabetes have a higher prevalence of elevated ACR than youth with type 1 diabetes, in an association that apparently does not completely depend on age, duration of diabetes, race/ethnicity, sex, level of glycemic control, or features of insulin resistance.
Authors: Dawn Konrad-Martin; Kelly M Reavis; Donald Austin; Nicholas Reed; Jane Gordon; Dan McDermott; Marilyn F Dille Journal: Ear Hear Date: 2015 Jul-Aug Impact factor: 3.570
Authors: Ruth S Weinstock; Paula M Trief; Laure El Ghormli; Robin Goland; Siripoom McKay; Kerry Milaszewski; Jeff Preske; Steven Willi; Patrice M Yasuda Journal: Diabetes Care Date: 2015-03-17 Impact factor: 19.112
Authors: Dawn Konrad-Martin; Curtis J Billings; Garnett P McMillan; Daniel McDermott; Jane Gordon; Donald Austin; Marilyn F Dille Journal: Ear Hear Date: 2016 May-Jun Impact factor: 3.570
Authors: Ronny A Bell; Elizabeth J Mayer-Davis; Jennifer W Beyer; Ralph B D'Agostino; Jean M Lawrence; Barbara Linder; Lenna L Liu; Santica M Marcovina; Beatriz L Rodriguez; Desmond Williams; Dana Dabelea Journal: Diabetes Care Date: 2009-03 Impact factor: 19.112
Authors: R Paul Wadwa; Elaine M Urbina; Andrea M Anderson; Richard F Hamman; Lawrence M Dolan; Beatriz L Rodriguez; Stephen R Daniels; Dana Dabelea Journal: Diabetes Care Date: 2010-01-12 Impact factor: 19.112