| Literature DB >> 17628701 |
Niall Stewart1, Bruce Taylor, Anne-Louise Ponsonby, Fotini Pittas, Ingrid van der Mei, Greg Woods, Haydn Walters.
Abstract
We measured the levels of IFNgamma, TNFalpha, Il-4 and Il-10 produced by mitogen-stimulated peripheral blood mononuclear cells (PBMC) from healthy people, and those with the relapse/remitting form of multiple sclerosis. Blood was taken in summer and winter. Healthy people had a summer excess of Il-4, Il-10 and TNFalpha, and a winter excess of IFNgamma. Untreated MS cases had a summer excess of Il-10, whereas those treated with Interferon-beta had lower levels of all cytokines, and displayed no seasonal effect.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17628701 DOI： 10.1016/j.jneuroim.2007.06.012
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478