| Literature DB >> 17628550 |
Kazutetsu Aoshiba1, Atsushi Nagai.
Abstract
To determine whether aging is associated with a pro-inflammatory shift in the lung, inflammation and inflammation-related gene expression in the lungs of 12-week-old and 24-month-old Balb/c mice were studied. cDNA microarray and quantitative reverse transcription-polymerase chain reaction analyses showed that eight inflammation-related genes, including CD20, Burkitt lymphoma receptor 1, CXCR-3, provirus integration site for Moloney murine leukemia virus-2, CD72, IL-8RB, C-Fgr, and CD8beta, were upregulated in the aged mice. Immunohistochemistry showed that the lungs of the aged mice contained increased numbers of CD4 cells, CD8 cells, B cells and macrophages. These results suggest that a pro-inflammatory shift occurs in the lungs of mice with aging.Entities:
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Year: 2007 PMID： 17628550 DOI： 10.1016/j.febslet.2007.06.075
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124