Literature DB >> 17628212

Blockade of the nociceptin/orphanin FQ/NOP receptor system in the rat ventrolateral periaqueductal gray potentiates DAMGO analgesia.

Giovanna M Scoto1, Giuseppina Aricò, Simone Ronsisvalle, Carmela Parenti.   

Abstract

Nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) are involved in various biological functions including pain. High density of NOP receptor has been found in the ventrolateral periaqueductal gray (vlPAG), the main output pathway involved in descending pain-control system. The aim of our work was to evaluate the involvement of the N/OFQ/NOP system in the modulation of MOP analgesia in the rat vlPAG using UFP-101, a selective NOP antagonist. N/OFQ significantly blocked DAMGO (a selective MOP agonist) analgesia, while UFP-101 enhanced the effect of the opioid given at a subanalgesic dose. These results confirm our hypothesis of an antiopioid role for N/OFQ in the vlPAG.

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Year:  2007        PMID： 17628212     DOI： 10.1016/j.peptides.2007.05.013

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  4 in total

Review 1.  Current research on opioid receptor function.

Authors:  Yuan Feng; Xiaozhou He; Yilin Yang; Dongman Chao; Lawrence H Lazarus; Ying Xia
Journal:  Curr Drug Targets       Date:  2012-02       Impact factor: 3.465

2.  Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain.

Authors:  Karel Guillemyn; Joanna Starnowska; Camille Lagard; Jolanta Dyniewicz; Ewelina Rojewska; Joanna Mika; Nga N Chung; Valérie Utard; Piotr Kosson; Andrzej W Lipkowski; Lucie Chevillard; Pol Arranz-Gibert; Meritxell Teixidó; Bruno Megarbane; Dirk Tourwé; Frédéric Simonin; Barbara Przewlocka; Peter W Schiller; Steven Ballet
Journal:  J Med Chem       Date:  2016-04-14       Impact factor: 7.446

3.  Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gαo protein.

Authors:  Jennifer T Lamberts; Chelsea E Smith; Ming-Hua Li; Susan L Ingram; Richard R Neubig; John R Traynor
Journal:  J Neurosci       Date:  2013-03-06       Impact factor: 6.167

Review 4.  Cellular and circuit diversity determines the impact of endogenous opioids in the descending pain modulatory pathway.

Authors:  Kylie B McPherson; Susan L Ingram
Journal:  Front Syst Neurosci       Date:  2022-08-15
  4 in total

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