| Literature DB >> 17627828 |
Gloria V López1, Fabiana Blanco, Paola Hernández, Ana Ferreira, Oscar E Piro, Carlos Batthyány, Mercedes González, Homero Rubbo, Hugo Cerecetto.
Abstract
Synthesis, physicochemical, and biological characterization of a series of alpha-tocopherol mimetics with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties and mammal cytotoxic activities. The lipophilic-hydrophilic balance of all products was also evaluated. A new hybrid furoxan, phenol derivative 17, possesses adequate profile of the studied properties.Entities:
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Year: 2007 PMID： 17627828 DOI： 10.1016/j.bmc.2007.06.019
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641