PURPOSE: The present analyses aimed to determine risk factors for rectal cancer patients associated with circumferential resection margin (CRM) and number of examined lymph nodes (LN) and to correlate these parameters of surgical quality with local recurrence (LR), disease-free and overall survival (DFS and OS). MATERIALS AND METHODS: Data of 884 eligible patients, who underwent a resection and had no metastases at time of surgery, were analysed. RESULTS: Age, period of treatment, distance and pT-stage were associated with surgical quality. CRM involvement, but not the number of examined LN, was associated with a higher risk of an LR, reduced DFS and OS. An abdomino-perineal resection (APR) was a risk factor for adverse outcome. CONCLUSION:Surgical quality is an important predictor of outcome, also for patients treated with conventional RT or chemoradiotherapy (CRT). Preoperative CRT results in downstaging and downsizing of the tumour, but not in less CRM involvement.
RCT Entities:
PURPOSE: The present analyses aimed to determine risk factors for rectal cancerpatients associated with circumferential resection margin (CRM) and number of examined lymph nodes (LN) and to correlate these parameters of surgical quality with local recurrence (LR), disease-free and overall survival (DFS and OS). MATERIALS AND METHODS: Data of 884 eligible patients, who underwent a resection and had no metastases at time of surgery, were analysed. RESULTS: Age, period of treatment, distance and pT-stage were associated with surgical quality. CRM involvement, but not the number of examined LN, was associated with a higher risk of an LR, reduced DFS and OS. An abdomino-perineal resection (APR) was a risk factor for adverse outcome. CONCLUSION: Surgical quality is an important predictor of outcome, also for patients treated with conventional RT or chemoradiotherapy (CRT). Preoperative CRT results in downstaging and downsizing of the tumour, but not in less CRM involvement.
Authors: Jose M Enríquez-Navascués; Nerea Borda; Aintzane Lizerazu; Carlos Placer; Jose L Elosegui; Juan P Ciria; Adelaida Lacasta; Luis Bujanda Journal: World J Gastroenterol Date: 2011-04-07 Impact factor: 5.742
Authors: Maria C Russell; Y Nancy You; Chung-Yuan Hu; Janice N Cormier; Barry W Feig; John M Skibber; Miguel A Rodriguez-Bigas; Heidi Nelson; George J Chang Journal: JAMA Surg Date: 2013-08 Impact factor: 14.766
Authors: S W Bell; A G Heriot; S K Warrier; C K Farmer; A R L Stevenson; I Bissett; J C Kong; M Solomon Journal: Tech Coloproctol Date: 2019-08-22 Impact factor: 3.781