Literature DB >> 17627585

Heme oxygenase-1: a fundamental guardian against oxidative tissue injuries in acute inflammation.

T Takahashi1, H Shimizu, H Morimatsu, K Inoue, R Akagi, K Morita, S Sassa.   

Abstract

Free heme contributes as a major threat to the oxidative tissue injuries because it catalyzes the formation of reactive oxygen species. When free heme concentration is increased, it results in the induction of heme oxygenase-1 (HO-1), which then breaks free heme down. As such, HO-1 plays a pivotal role in the protection of tissues from oxidative injuries.

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Year:  2007        PMID： 17627585     DOI： 10.2174/138955707781024517

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  20 in total

1.  Manganese potentiates LPS-induced heme-oxygenase 1 in microglia but not dopaminergic cells: role in controlling microglial hydrogen peroxide and inflammatory cytokine output.

Authors:  Celia A Dodd; Nikolay M Filipov
Journal:  Neurotoxicology       Date:  2011-09-25       Impact factor: 4.294

2.  Bach1-dependent and -independent regulation of heme oxygenase-1 in keratinocytes.

Authors:  Shuko Okada; Akihiko Muto; Eisaku Ogawa; Ayako Nakanome; Yasutake Katoh; Shuntaro Ikawa; Setsuya Aiba; Kazuhiko Igarashi; Ryuhei Okuyama
Journal:  J Biol Chem       Date:  2010-05-25       Impact factor: 5.157

3.  Pharmacologic suppression of inflammation by a diphenyldifluoroketone, EF24, in a rat model of fixed-volume hemorrhage improves survival.

Authors:  Vivek R Yadav; Kaustuv Sahoo; Pamela R Roberts; Vibhudutta Awasthi
Journal:  J Pharmacol Exp Ther       Date:  2013-08-30       Impact factor: 4.030

4.  Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of Group VIB Ca2+-independent phospholipase A2gamma-deficient mice.

Authors:  Emiko Yoda; Keiko Hachisu; Yoshitaka Taketomi; Kotomi Yoshida; Masanori Nakamura; Kazutaka Ikeda; Ryo Taguchi; Yoshihito Nakatani; Hiroshi Kuwata; Makoto Murakami; Ichiro Kudo; Shuntaro Hara
Journal:  J Lipid Res       Date:  2010-07-12       Impact factor: 5.922

5.  Induction of heme oxygenase-1 shifts the balance from proinjury to prosurvival in the placentas of pregnant rats with reduced uterine perfusion pressure.

Authors:  Eric M George; Istvan Arany
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2012-01-11       Impact factor: 3.619

6.  Down-regulation of aminolevulinate synthase, the rate-limiting enzyme for heme biosynthesis in Alzheimer's disease.

Authors:  Barney E Dwyer; Mark A Smith; Sandy L Richardson; George Perry; Xiongwei Zhu
Journal:  Neurosci Lett       Date:  2009-05-27       Impact factor: 3.046

7.  Phagocyte migration and cellular stress induced in liver, lung, and intestine during sleep loss and sleep recovery.

Authors:  Carol A Everson; Christa D Thalacker; Neil Hogg
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2008-10-22       Impact factor: 3.619

8.  Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells.

Authors:  Shyamali Basuroy; Sujoy Bhattacharya; Charles W Leffler; Helena Parfenova
Journal:  Am J Physiol Cell Physiol       Date:  2008-12-31       Impact factor: 4.249

Review 9.  Targeting the redox balance in inflammatory skin conditions.

Authors:  Frank A D T G Wagener; Carine E Carels; Ditte M S Lundvig
Journal:  Int J Mol Sci       Date:  2013-04-26       Impact factor: 5.923

10.  Heme oxygenase-1: its therapeutic roles in inflammatory diseases.

Authors:  Hyun-Ock Pae; Hun-Taeg Chung
Journal:  Immune Netw       Date:  2009-02-28       Impact factor: 6.303
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