OBJECTIVE: To evaluate the effect activity has on the vaginal distribution of a 1200 mg miconazole nitrate gelatin encapsulated insert, an antifungal agent commonly used to treat vaginal vulvocandidiasis. METHOD: Nine subjects underwent two sessions of serial magnetic resonance imaging after insertion of the insert. One session required that the subjects ambulate between images; the other session required the subjects remain supine between images. Vaginal distribution of the insert was quantified by calculating surface contact and linear distance in every image. Comparison of spread was then done between images taken in active subjects and images taken in resting subjects. Time until capsule dissolution was also compared between the two groups. RESULTS: No statistically significant difference was seen in spread of insert between the active and resting group. Activity also had no significant effect on capsule dissolution. CONCLUSION: Activity does not appear to hinder the spread of the insert, suggesting that this medication can be used daytime or nighttime.
OBJECTIVE: To evaluate the effect activity has on the vaginal distribution of a 1200 mg miconazole nitrate gelatin encapsulated insert, an antifungal agent commonly used to treat vaginal vulvocandidiasis. METHOD: Nine subjects underwent two sessions of serial magnetic resonance imaging after insertion of the insert. One session required that the subjects ambulate between images; the other session required the subjects remain supine between images. Vaginal distribution of the insert was quantified by calculating surface contact and linear distance in every image. Comparison of spread was then done between images taken in active subjects and images taken in resting subjects. Time until capsule dissolution was also compared between the two groups. RESULTS: No statistically significant difference was seen in spread of insert between the active and resting group. Activity also had no significant effect on capsule dissolution. CONCLUSION: Activity does not appear to hinder the spread of the insert, suggesting that this medication can be used daytime or nighttime.
Authors: Nicolette A Louissaint; Edward J Fuchs; Rahul P Bakshi; Sridhar Nimmagadda; Yong Du; Katarzyna J Macura; Karen E King; Richard Wahl; Arthur J Goldsmith; Brian Caffo; Ying Jun Cao; Jean Anderson; Craig W Hendrix Journal: J Infect Dis Date: 2012-01-25 Impact factor: 5.226