BACKGROUND: Several studies indicate that heart transplantation (HTx) is associated with depression and reduced quality of life. However, the impact of depression on the prognosis for HTx-patients has not yet been sufficiently established. The aim of the present study was to prospectively investigate the influence of depression on mortality in patients with HTx, adjusting for other known risk factors. METHODS: In a prospective, cross-sectional study with minimum 5-year follow-up, symptoms of depression were assessed in 147 HTx-patients using the Beck Depression Inventory (BDI). RESULTS: Mild to severe depressive symptoms (BDI > or =10) were observed in 36 patients (24.5%). Depressive symptoms on inclusion increased the risk of mortality during the follow-up period. The risk remained significant after adjusting for several somatic and lifestyle risk factors, and the adjusted relative risk associated with depression (risk ratio: 2.32; 95% CI: 1.13-4.79; P=0.02) was comparable to the adjusted relative risk associated with time since HTx. CONCLUSIONS: Symptoms of depression predict mortality independently of somatic and lifestyle risk factors in HTx patients, and this group of patients should be screened for depressive symptoms.
BACKGROUND: Several studies indicate that heart transplantation (HTx) is associated with depression and reduced quality of life. However, the impact of depression on the prognosis for HTx-patients has not yet been sufficiently established. The aim of the present study was to prospectively investigate the influence of depression on mortality in patients with HTx, adjusting for other known risk factors. METHODS: In a prospective, cross-sectional study with minimum 5-year follow-up, symptoms of depression were assessed in 147 HTx-patients using the Beck Depression Inventory (BDI). RESULTS: Mild to severe depressive symptoms (BDI > or =10) were observed in 36 patients (24.5%). Depressive symptoms on inclusion increased the risk of mortality during the follow-up period. The risk remained significant after adjusting for several somatic and lifestyle risk factors, and the adjusted relative risk associated with depression (risk ratio: 2.32; 95% CI: 1.13-4.79; P=0.02) was comparable to the adjusted relative risk associated with time since HTx. CONCLUSIONS: Symptoms of depression predict mortality independently of somatic and lifestyle risk factors in HTxpatients, and this group of patients should be screened for depressive symptoms.
Authors: Emily M Rosenberger; Andrea F DiMartini; Annette J DeVito Dabbs; Christian A Bermudez; Joseph M Pilewski; Yoshiya Toyoda; Mary Amanda Dew Journal: Transplantation Date: 2016-01 Impact factor: 4.939
Authors: Corinne M Anton; Morgan B Drake; Ryan J Butts; Thi Cao; Afsaneh Rezaeizadeh; Madhukar H Trivedi; Kelli N Triplett Journal: J Clin Psychol Med Settings Date: 2021-03-27
Authors: Mary Amanda Dew; Emily M Rosenberger; Larissa Myaskovsky; Andrea F DiMartini; Annette J DeVito Dabbs; Donna M Posluszny; Jennifer Steel; Galen E Switzer; Diana A Shellmer; Joel B Greenhouse Journal: Transplantation Date: 2015-05 Impact factor: 4.939
Authors: Karl-Heinz Ladwig; Florian Lederbogen; Christian Albus; Christiane Angermann; Martin Borggrefe; Denise Fischer; Kurt Fritzsche; Markus Haass; Jochen Jordan; Jana Jünger; Ingrid Kindermann; Volker Köllner; Bernhard Kuhn; Martin Scherer; Melchior Seyfarth; Heinz Völler; Christiane Waller; Christoph Herrmann-Lingen Journal: Ger Med Sci Date: 2014-05-07