The molecular control of and clinical variations in root formation.

Roots of teeth perform critical functions to anchor the teeth in the jaws and transmit the masticatory forces in such a way as to minimize fracture and wear of the dentition. Tooth root development involves a variety of cell types, epithelial-mesenchymal interactions, the enumeration of specialized extracellular matrices, processing of these matrices and strict control over the microenvironment to allow the cementum and dentin to mineralize. While many of the specific molecular mechanisms involved in root formation remain poorly understood, our knowledge of these events and pathways has advanced markedly over the past decade. The molecular bases of many hereditary conditions having associated dental root anomalies are now known. Therapeutic approaches based on the molecular biology of root formation have and will continue to emerge and be translated into improved clinical care. The purpose of this study was to review our knowledge regarding developmental defects of root formation, the molecular mechanisms involved, and the impact of root variants on clinical dentistry. Copyright 2007 S. Karger AG, Basel.