OBJECTIVES: To describe the antimicrobial susceptibility profile of isolated Vibrio cholerae O1 serotype Ogawa recovered from patients admitted to the cholera facility in the Manhiça District Hospital (MDH), Mozambique. METHODS: Rectal swabs were collected from patients with complaints symptomatic of cholera admitted to the MDH cholera facility. Samples were processed for V. cholerae isolation at the Centro de Investigação em Saúde da Manhiça (CISM) and identified by biochemical reaction. Serotypes were determined by slide-agglutination antisera. Susceptibilities were determined by disc diffusion. RESULTS: Seventy-seven isolates were examined for their resistance profile. High incidences of antimicrobial resistance were found for chloramphenicol (57.9%), co-trimoxazole (96.6%) and tetracycline (97.3%). Quinolone resistance remained low (4.2%). CONCLUSIONS: Although V. cholerae infections in Africa do not usually require antimicrobial treatment, strains in rural Mozambique show high incidences of resistance to readily available drugs. When appropriate, quinolones or third-generation cephalosporins can be used as treatment options.
OBJECTIVES: To describe the antimicrobial susceptibility profile of isolated Vibrio cholerae O1 serotype Ogawa recovered from patients admitted to the cholera facility in the Manhiça District Hospital (MDH), Mozambique. METHODS: Rectal swabs were collected from patients with complaints symptomatic of cholera admitted to the MDH cholera facility. Samples were processed for V. cholerae isolation at the Centro de Investigação em Saúde da Manhiça (CISM) and identified by biochemical reaction. Serotypes were determined by slide-agglutination antisera. Susceptibilities were determined by disc diffusion. RESULTS: Seventy-seven isolates were examined for their resistance profile. High incidences of antimicrobial resistance were found for chloramphenicol (57.9%), co-trimoxazole (96.6%) and tetracycline (97.3%). Quinolone resistance remained low (4.2%). CONCLUSIONS: Although V. cholerae infections in Africa do not usually require antimicrobial treatment, strains in rural Mozambique show high incidences of resistance to readily available drugs. When appropriate, quinolones or third-generation cephalosporins can be used as treatment options.
Authors: Mohammad S Islam; Zahid H Mahmud; Mohammad Ansaruzzaman; Shah M Faruque; Kaisar A Talukder; Firdausi Qadri; Munirul Alam; Shafiqul Islam; Pradip K Bardhan; Ramendra N Mazumder; Azharul I Khan; Sirajuddin Ahmed; Anwarul Iqbal; Owen Chitsatso; James Mudzori; Sheetal Patel; Stanley M Midzi; Lincoln Charimari; Hubert P Endtz; Alejandro Cravioto Journal: J Clin Microbiol Date: 2011-04-06 Impact factor: 5.948
Authors: Irin Parvin; K M Shahunja; Soroar Hossain Khan; Tahmina Alam; Lubaba Shahrin; Mst Mahmuda Ackhter; Monira Sarmin; Sampa Dash; Muhammad Waliur Rahman; Abu Sadat Mohammad Sayeem Bin Shahid; Abu Syed Golam Faruque; Tahmeed Ahmed; Mohammod Jobayer Chisti Journal: Am J Trop Med Hyg Date: 2020-05-21 Impact factor: 2.345
Authors: Huu Dat Tran; Munirul Alam; Nguyen Vu Trung; Nguyen Van Kinh; Hong Ha Nguyen; Van Ca Pham; Mohammad Ansaruzzaman; Shah Manzur Rashed; Nurul A Bhuiyan; Tuyet Trinh Dao; Hubert P Endtz; Heiman F L Wertheim Journal: J Med Microbiol Date: 2011-10-20 Impact factor: 2.472