BACKGROUND & AIMS: The Utah Population Database (UPDB) is unique; it links genealogy for over 2 million Utah individuals to a statewide Cancer Registry. We have investigated the familial nature of rectal cancer, considered independently from colon cancer. METHODS: We estimated relative risks in relatives, and average relatedness among rectal cancer patients using matched controls from the UPDB. RESULTS: There is a significant increased risk for rectal cancer in first-degree relatives of rectal cancer patients (relative risk [RR], 1.97), equivalent to the risk for colon cancer (RR, 2.11). The significant increased risk for rectal cancer extends to second- and third-degree relatives. The RR for rectal cancer among first-degree relatives of young-onset rectal cancer patients (<55 y), is equivalent (RR, 3.34) to their risk of colon cancer (RR, 3.35). CONCLUSIONS: The UPDB provides strong evidence for a familial component to rectal cancer that may include a genetic component in addition to shared environment. There is a significant increased risk of rectal cancer in the close and distant relatives of rectal cancer patients, which is even higher among relatives of young-onset patients. Although it has been reported that relatives of colon cancer probands are at increased risk for colorectal cancer, the risk of large-bowel cancer among relatives of rectal cancer patients has been less clear. Relatives of rectal cancer probands experience a risk of cancer of the large bowel that is at least as high as the risk previously reported for relatives of individuals with colon cancer.
BACKGROUND & AIMS: The Utah Population Database (UPDB) is unique; it links genealogy for over 2 million Utah individuals to a statewide Cancer Registry. We have investigated the familial nature of rectal cancer, considered independently from colon cancer. METHODS: We estimated relative risks in relatives, and average relatedness among rectal cancerpatients using matched controls from the UPDB. RESULTS: There is a significant increased risk for rectal cancer in first-degree relatives of rectal cancerpatients (relative risk [RR], 1.97), equivalent to the risk for colon cancer (RR, 2.11). The significant increased risk for rectal cancer extends to second- and third-degree relatives. The RR for rectal cancer among first-degree relatives of young-onset rectal cancerpatients (<55 y), is equivalent (RR, 3.34) to their risk of colon cancer (RR, 3.35). CONCLUSIONS: The UPDB provides strong evidence for a familial component to rectal cancer that may include a genetic component in addition to shared environment. There is a significant increased risk of rectal cancer in the close and distant relatives of rectal cancerpatients, which is even higher among relatives of young-onset patients. Although it has been reported that relatives of colon cancer probands are at increased risk for colorectal cancer, the risk of large-bowel cancer among relatives of rectal cancerpatients has been less clear. Relatives of rectal cancer probands experience a risk of cancer of the large bowel that is at least as high as the risk previously reported for relatives of individuals with colon cancer.
Authors: Louise E Johns; Frank Kee; Brendan J Collins; Christopher C Patterson; Richard S Houlston Journal: Dis Colon Rectum Date: 2002-05 Impact factor: 4.585
Authors: S Sveinbjörnsdottir; A A Hicks; T Jonsson; H Pétursson; G Guğmundsson; M L Frigge; A Kong; J R Gulcher; K Stefansson Journal: N Engl J Med Date: 2000-12-14 Impact factor: 91.245
Authors: Lisa A Cannon Albright; Nicola J Camp; James M Farnham; Joel MacDonald; Keyvan Abtin; Kerry G Rowe Journal: J Neurosurg Date: 2003-10 Impact factor: 5.115
Authors: Aung Ko Win; Rhiannon J Walters; Daniel D Buchanan; Mark A Jenkins; Kevin Sweet; Wendy L Frankel; Albert de la Chapelle; Diane M McKeone; Michael D Walsh; Mark Clendenning; Sally-Ann Pearson; Erika Pavluk; Belinda Nagler; John L Hopper; Michael R Gattas; Jack Goldblatt; Jill George; Graeme K Suthers; Kerry D Phillips; Sonja Woodall; Julie Arnold; Kathy Tucker; Michael Field; Sian Greening; Steve Gallinger; Melyssa Aronson; Renee Perrier; Michael O Woods; Jane S Green; Neal Walker; Christophe Rosty; Susan Parry; Joanne P Young Journal: Am J Gastroenterol Date: 2012-04-24 Impact factor: 10.864
Authors: Jan T Lowery; Dennis J Ahnen; Paul C Schroy; Heather Hampel; Nancy Baxter; C Richard Boland; Randall W Burt; Lynn Butterly; Megan Doerr; Mary Doroshenk; W Gregory Feero; Nora Henrikson; Uri Ladabaum; David Lieberman; Elizabeth G McFarland; Susan K Peterson; Martha Raymond; N Jewel Samadder; Sapna Syngal; Thomas K Weber; Ann G Zauber; Robert Smith Journal: Cancer Date: 2016-06-03 Impact factor: 6.860