Literature DB >> 17625891

A concise asymmetric synthesis of torcetrapib.

Meritxell Guinó1, Pim Huat Phua, Jean-Claude Caille, King Kuok Mimi Hii.   

Abstract

Optically active torcetrapib was synthesized in seven steps from achiral precursors without the need for protecting groups, utilizing an enantioselective aza-Michael reaction to achieve asymmetry.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17625891     DOI： 10.1021/jo071031g

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  2 in total

1.  Preparation of dicationic palladium catalysts for asymmetric catalytic reactions.

Authors:  Andrey E Sheshenev; Alexander M R Smith; King Kuok Mimi Hii
Journal:  Nat Protoc       Date:  2012-09-06       Impact factor: 13.491

2.  Facile synthesis of functionalized tetrahydroquinolines via domino Povarov reactions of arylamines, methyl propiolate and aromatic aldehydes.

Authors:  Jing Sun; Hong Gao; Qun Wu; Chao-Guo Yan
Journal:  Beilstein J Org Chem       Date:  2012-10-26       Impact factor: 2.883
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.