Literature DB >> 17625766

Short-interfering RNAs as antivirals against rabies.

Paulo Eduardo Brandão1, Juliana Galera Castilho, Willian Fahl, Pedro Carnieli, Rafael de Novaes Oliveira, Carla Isabel Macedo, Maria Luiza Carrieri, Ivanete Kotait.   

Abstract

This study aimed to test in vitro a RNA-interference based antiviral approach for rabies with short-interfering RNAs (siRNAs) against rabies virus nucleoprotein mRNA. BHK-21 cells were infected with serial dilutions of PV rabies virus strain and transfected with a pool of three siRNAs. Direct immunofluorescence staining showed a 5-time decrease in virus titer when compared to a non-treated plate, showing a promising new approach to the development of antivirals for rabies treatment.

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Year:  2007        PMID： 17625766     DOI： 10.1590/s1413-86702007000200011

Source DB:  PubMed          Journal:  Braz J Infect Dis        ISSN： 1413-8670            Impact factor:   1.949


  11 in total

1.  Bufotenine, a tryptophan-derived alkaloid, suppresses the symptoms and increases the survival rate of rabies-infected mice: the development of a pharmacological approach for rabies treatment.

Authors:  Hugo Vigerelli; Juliana M Sciani; Patricia M C Pereira; Aline A Lavezo; Andrea C R Silva; Rita C O Collaço; Thalita Rocha; Thais C Bueno; Daniel C Pimenta
Journal:  J Venom Anim Toxins Incl Trop Dis       Date:  2020-02-03

Review 2.  Rabies Control and Treatment: From Prophylaxis to Strategies with Curative Potential.

Authors:  Shimao Zhu; Caiping Guo
Journal:  Viruses       Date:  2016-10-28       Impact factor: 5.048

3.  Intracerebral delivery of small interfering RNAs (siRNAs) using adenoviral vector protects mice against lethal peripheral rabies challenge.

Authors:  Praveen K Gupta; Arvind A Sonwane; Niraj K Singh; Chetan D Meshram; Shyam S Dahiya; Sachin S Pawar; Swatantra P Gupta; V K Chaturvedi; Mohini Saini
Journal:  Virus Res       Date:  2011-08-16       Impact factor: 3.303

Review 4.  A review on current status of antiviral siRNA.

Authors:  Abid Qureshi; Vaqar Gani Tantray; Altaf Rehman Kirmani; Abdul Ghani Ahangar
Journal:  Rev Med Virol       Date:  2018-04-15       Impact factor: 6.989

5.  In vitro and in vivo inhibition of rabies virus replication by RNA interference.

Authors:  Ekaterina A Durymanova Ono; Keila Iamamoto; Juliana G Castilho; Pedro Carnieli; Rafael de Novaes Oliveira; Samira M Achkar; Maria L Carrieri; Ivanete Kotait; Paulo E Brandão
Journal:  Braz J Microbiol       Date:  2013-11-15       Impact factor: 2.476

6.  Adeno-associated viruses serotype 2-mediated RNA interference efficiently inhibits rabies virus replication in vitro and in vivo.

Authors:  Hong-Xia Wu; Hua-Lei Wang; Xiao-Feng Guo; Yu-Jiao Yang; Jin-Zhu Ma; Tie-Cheng Wang; Yu-Wei Gao; Yong-Kun Zhao; Song-Tao Yang; Xian-Zhu Xia
Journal:  J Vet Med Sci       Date:  2013-07-14       Impact factor: 1.267

Review 7.  Small Non-coding RNAs Associated with Viral Infectious Diseases of Veterinary Importance: Potential Clinical Applications.

Authors:  Mohamed Samir; Frank Pessler
Journal:  Front Vet Sci       Date:  2016-04-04

Review 8.  Subversion of the Immune Response by Rabies Virus.

Authors:  Terence P Scott; Louis H Nel
Journal:  Viruses       Date:  2016-08-19       Impact factor: 5.048

9.  Small interfering RNAs targeting the rabies virus nucleoprotein gene.

Authors:  Yu-Jiao Yang; Ping-Sen Zhao; Tao Zhang; Hua-Lei Wang; Hong-Ru Liang; Li-Li Zhao; Hong-Xia Wu; Tie-Cheng Wang; Song-Tao Yang; Xian-Zhu Xia
Journal:  Virus Res       Date:  2012-08-03       Impact factor: 3.303

10.  Protection of mice against lethal rabies virus challenge using short interfering RNAs (siRNAs) delivered through lentiviral vector.

Authors:  Niraj K Singh; Chetan D Meshram; Arvind A Sonwane; Shyam S Dahiya; Sachin S Pawar; V K Chaturvedi; Mohini Saini; R P Singh; Praveen K Gupta
Journal:  Mol Biotechnol       Date:  2014-02       Impact factor: 2.695
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