| Literature DB >> 17624773 |
Lynda Loudni1, Joëlle Roche, Vincent Potiron, Jonathan Clarhaut, Christian Bachmann, Jean-Pierre Gesson, Isabelle Tranoy-Opalinski.
Abstract
New histone deacetylase inhibitors have been synthesized and evaluated for their activity against non-small lung cancer cell line H661. These compounds have been designed with diversely substituted 1,4-benzodiazepine-2,5-dione moieties as cyclic peptide mimic cap structures, and a hydroxamate side chain. Biological evaluations demonstrated that benzodiazepine-based HDACi bearing an aromatic substituent at the N1 position exhibited promising antiproliferative and HDAC-inhibitory activities.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17624773 DOI： 10.1016/j.bmcl.2007.06.067
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823