Literature DB >> 17624629

Association study of the paraoxonase 1 gene with the risk of developing Alzheimer's disease.

Julien Chapuis1, Maud Boscher, Faiza Bensemain, Dominique Cottel, Philippe Amouyel, Jean-Charles Lambert.   

Abstract

Recently, a region encompassing the promoter and intron 1 of the paraoxonase 1 gene (PON1) have been associated with the risk of developing Alzheimer's disease (AD) in a large pan-ethnic (Caucasian and African-American) dataset. We attempted to replicate this observation in a large French study of sporadic cases and controls. We confirmed that the proximal promoter and 5' sequence of the PON1 gene may harbor unknown functional variant(s) associated with the risk of developing AD.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17624629     DOI： 10.1016/j.neurobiolaging.2007.05.021

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  7 in total

1.  Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.

Authors:  Porat M Erlich; Kathryn L Lunetta; L Adrienne Cupples; Carmela R Abraham; Robert C Green; Clinton T Baldwin; Lindsay A Farrer
Journal:  Neurobiol Aging       Date:  2010-10-27       Impact factor: 4.673

2.  Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: a case control study.

Authors:  Lisa F Potts; Alex C Cambon; Owen A Ross; Rosa Rademakers; Dennis W Dickson; Ryan J Uitti; Zbigniew K Wszolek; Shesh N Rai; Matthew J Farrer; David W Hein; Irene Litvan
Journal:  BMC Med Genet       Date:  2012-03-17       Impact factor: 2.103

Review 3.  Paraoxonase 1 Q192R and L55M polymorphisms and susceptibility to amyotrophic lateral sclerosis: a meta-analysis.

Authors:  Young Ho Lee; Jae-Hoon Kim; Young Ho Seo; Sung Jae Choi; Jong Dae Ji; Gwan Gyu Song
Journal:  Neurol Sci       Date:  2014-10-10       Impact factor: 3.307

Review 4.  Paraoxonase 1 in neurological disorders.

Authors:  Teresita Menini; Alejandro Gugliucci
Journal:  Redox Rep       Date:  2013-11-12       Impact factor: 4.412

Review 5.  The Relevance of Noncoding DNA Variations of Paraoxonase Gene Cluster in Atherosclerosis-Related Diseases.

Authors:  Anna Wysocka; Agnieszka Zwolak
Journal:  Int J Mol Sci       Date:  2021-02-21       Impact factor: 5.923

6.  Alzheimer's Disease and Paraoxonase 1 (PON1) Gene Polymorphisms.

Authors:  Mohsen Saeidi; Raheleh Shakeri; Abdoljalal Marjani; Safoura Khajeniazi
Journal:  Open Biochem J       Date:  2017-06-13

7.  Profile of the Paraoxonase 1 (PON1) Gene 192Q/R Polymorphism and Clinical Associations among Older Singaporean Chinese with Alzheimer's and Mixed Dementia.

Authors:  Dennis C C Seow; Qi Gao; Philip Yap; Jia Min Gan; Hui Ling Chionh; Su Chi Lim; Lei Feng; Tze Pin Ng
Journal:  Dement Geriatr Cogn Dis Extra       Date:  2016-02-17
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.