Literature DB >> 17623910

Calcium signaling, ion channels and more. The DT40 system as a model of vertebrate ion homeostasis and cell physiology.

Anne-Laure Perraud1, Carsten Schmitz, Andrew M Scharenberg.   

Abstract

The DT40 B-lymphocyte cell line is a chicken bursal lymphocyte tumor cell line which grows rapidly, expresses a variety of types of constitutive and signal dependent ion transport systems., and supports the efficient use of stable and conditional genetic manipulations. Below, we review the use of DT40 cells in dissecting molecular mechanisms involved in Ca2+, Mg2+, and Zn2+ transport physiology. These studies highlight the flexibility and advantages the DT40 environment offers to investigators interested in the study of basic vertebrate ion transport physiology.

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Year:  2006        PMID： 17623910      PMCID： PMC3628819     

Source DB:  PubMed          Journal:  Subcell Biochem        ISSN： 0306-0225


  23 in total

1.  Role of the phospholipase C-inositol 1,4,5-trisphosphate pathway in calcium release-activated calcium current and capacitative calcium entry.

Authors:  L M Broad; F J Braun; J P Lievremont; G S Bird; T Kurosaki; J W Putney
Journal:  J Biol Chem       Date:  2001-02-13       Impact factor: 5.157

2.  Expression of functional receptor-coupled TRPC3 channels in DT40 triple receptor InsP3 knockout cells.

Authors:  K Venkatachalam; H T Ma; D L Ford; D L Gill
Journal:  J Biol Chem       Date:  2001-07-20       Impact factor: 5.157

3.  Human Trp3 forms both inositol trisphosphate receptor-dependent and receptor-independent store-operated cation channels in DT40 avian B lymphocytes.

Authors:  G Vazquez; J P Lievremont; G St J Bird; J W Putney
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-11       Impact factor: 11.205

4.  Modification of store-operated channel coupling and inositol trisphosphate receptor function by 2-aminoethoxydiphenyl borate in DT40 lymphocytes.

Authors:  Hong-Tao Ma; Kartik Venkatachalam; Jan B Parys; Donald L Gill
Journal:  J Biol Chem       Date:  2001-12-10       Impact factor: 5.157

5.  Regulation of Ca2+-release-activated Ca2+ current (Icrac) by ryanodine receptors in inositol 1,4,5-trisphosphate-receptor-deficient DT40 cells.

Authors:  K Kiselyov; D M Shin; N Shcheynikov; T Kurosaki; S Muallem
Journal:  Biochem J       Date:  2001-11-15       Impact factor: 3.857

6.  Assessment of the role of the inositol 1,4,5-trisphosphate receptor in the activation of transient receptor potential channels and store-operated Ca2+ entry channels.

Authors:  H T Ma; K Venkatachalam; H S Li; C Montell; T Kurosaki; R L Patterson; D L Gill
Journal:  J Biol Chem       Date:  2001-03-19       Impact factor: 5.157

7.  Potentiation and inhibition of Ca(2+) release-activated Ca(2+) channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP(3) receptors.

Authors:  M Prakriya; R S Lewis
Journal:  J Physiol       Date:  2001-10-01       Impact factor: 5.182

8.  LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability.

Authors:  M J Nadler; M C Hermosura; K Inabe; A L Perraud; Q Zhu; A J Stokes; T Kurosaki; J P Kinet; R Penner; A M Scharenberg; A Fleig
Journal:  Nature       Date:  2001-05-31       Impact factor: 49.962

9.  An inositol 1,4,5-trisphosphate receptor-dependent cation entry pathway in DT40 B lymphocytes.

Authors:  Guillermo Vazquez; Barbara J Wedel; Gary St J Bird; Suresh K Joseph; James W Putney
Journal:  EMBO J       Date:  2002-09-02       Impact factor: 11.598

10.  Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytes.

Authors:  Yasuo Mori; Minoru Wakamori; Tomoya Miyakawa; Meredith Hermosura; Yuji Hara; Motohiro Nishida; Kenzo Hirose; Akiko Mizushima; Mari Kurosaki; Emiko Mori; Kumiko Gotoh; Takaharu Okada; Andrea Fleig; Reinhold Penner; Masamitsu Iino; Tomohiro Kurosaki
Journal:  J Exp Med       Date:  2002-03-18       Impact factor: 14.307
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