Literature DB >> 17623905

Genetic analysis of B cell signaling.

Hisaaki Shinohara1, Tomohiro Kurosaki.   

Abstract

Recent evidence indicates that B lymphocytes are instructed continuously by B cell receptor (BCR) signals to make crucial cell-fate decisions at several checkpoints during their development and humoral immune responses, reinforcing the importance of studies of the BCR signals. One of the best cell lines for these studies is a chicken DT40 B-cell line, because a high propensity of homologous recombination in this cell line allows us to easily take both genetic and biochemical approaches. Here, based upon the recent data, mainly obtained from the DT40 system, we discuss several new aspects on mechanisms by which BCR signals are propagated and modified.

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Year:  2006        PMID： 17623905     DOI： 10.1007/978-1-4020-4896-8_10

Source DB:  PubMed          Journal:  Subcell Biochem        ISSN： 0306-0225


  11 in total

Review 1.  The cytoskeleton coordinates the early events of B-cell activation.

Authors:  Naomi E Harwood; Facundo D Batista
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-02-01       Impact factor: 10.005

2.  SLP-65 phosphorylation dynamics reveals a functional basis for signal integration by receptor-proximal adaptor proteins.

Authors:  Thomas Oellerich; Mads Grønborg; Konstantin Neumann; He-Hsuan Hsiao; Henning Urlaub; Jürgen Wienands
Journal:  Mol Cell Proteomics       Date:  2009-04-16       Impact factor: 5.911

3.  Mechanistic analysis of the amplification and diversification events induced by Vav proteins in B-lymphocytes.

Authors:  María J Caloca; José L Zugaza; Xosé R Bustelo
Journal:  J Biol Chem       Date:  2008-10-29       Impact factor: 5.157

4.  The Poly(ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes.

Authors:  Ben Buelow; Yumei Song; Andrew M Scharenberg
Journal:  J Biol Chem       Date:  2008-07-03       Impact factor: 5.157

5.  Single round of antigen receptor signaling programs naive B cells to receive T cell help.

Authors:  Bazarragchaa Damdinsuren; Yongqing Zhang; Ashraf Khalil; William H Wood; Kevin G Becker; Mark J Shlomchik; Ranjan Sen
Journal:  Immunity       Date:  2010-03-11       Impact factor: 31.745

6.  The reversible formation of cysteine sulfenic acid promotes B-cell activation and proliferation.

Authors:  Katie E Crump; Daniel G Juneau; Leslie B Poole; Karen M Haas; Jason M Grayson
Journal:  Eur J Immunol       Date:  2012-08       Impact factor: 5.532

7.  The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor.

Authors:  Bebhinn Treanor; David Depoil; Aitor Gonzalez-Granja; Patricia Barral; Michele Weber; Omer Dushek; Andreas Bruckbauer; Facundo D Batista
Journal:  Immunity       Date:  2010-02-18       Impact factor: 31.745

8.  Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen.

Authors:  Michele Weber; Bebhinn Treanor; David Depoil; Hisaaki Shinohara; Naomi E Harwood; Masaki Hikida; Tomohiro Kurosaki; Facundo D Batista
Journal:  J Exp Med       Date:  2008-03-24       Impact factor: 14.307

9.  Characterization of parameters required for effective use of tamoxifen-regulated recombination.

Authors:  Ben Buelow; Andrew M Scharenberg
Journal:  PLoS One       Date:  2008-09-23       Impact factor: 3.240

10.  Novel Pathways Revealed in Bursa of Fabricius Transcriptome in Response to Extraintestinal Pathogenic Escherichia coli (ExPEC) Infection.

Authors:  Hongyan Sun; Peng Liu; Lisa K Nolan; Susan J Lamont
Journal:  PLoS One       Date:  2015-11-10       Impact factor: 3.240
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