BACKGROUND: Convective blood purification improves beta(2)-microglobulin (beta(2)M) removal and may delay the onset of dialysis-related amyloidosis. We assessed the differential effects of high-flux haemodialysis (HD) and on-line haemodiafiltration (HDF) on plasma beta(2)M levels, given the enhanced convective capability of HDF. METHODS: We measured pre-dialysis beta(2)M levels in 297 patients in a programme employing both high-flux HD and HDF, then analysed the relationship of beta(2)M to modality and other variables. RESULTS: Independent determinants of plasma beta(2)M levels were residual renal function, age, HD vintage, and C-reactive protein load, but not the patient's predominant modality (high-flux HD or HDF). Patients with KRU levels <0.5 ml/min had significantly higher beta(2)M levels than patients with KRU between 0.5 and 1 ml/min. CONCLUSIONS: Residual renal function is of overriding importance as a determinant of beta(2)M levels in HD patients and may supersede enhanced convective clearance by HDF. Beneficial effects extend to very low levels of residual renal function. Copyright 2007 S. Karger AG, Basel.
BACKGROUND: Convective blood purification improves beta(2)-microglobulin (beta(2)M) removal and may delay the onset of dialysis-related amyloidosis. We assessed the differential effects of high-flux haemodialysis (HD) and on-line haemodiafiltration (HDF) on plasma beta(2)M levels, given the enhanced convective capability of HDF. METHODS: We measured pre-dialysis beta(2)M levels in 297 patients in a programme employing both high-flux HD and HDF, then analysed the relationship of beta(2)M to modality and other variables. RESULTS: Independent determinants of plasma beta(2)M levels were residual renal function, age, HD vintage, and C-reactive protein load, but not the patient's predominant modality (high-flux HD or HDF). Patients with KRU levels <0.5 ml/min had significantly higher beta(2)M levels than patients with KRU between 0.5 and 1 ml/min. CONCLUSIONS: Residual renal function is of overriding importance as a determinant of beta(2)M levels in HDpatients and may supersede enhanced convective clearance by HDF. Beneficial effects extend to very low levels of residual renal function. Copyright 2007 S. Karger AG, Basel.
Authors: Stephanie M Toth-Manikowski; Tammy L Sirich; Timothy W Meyer; Thomas H Hostetter; Seungyoung Hwang; Natalie S Plummer; Xin Hai; Josef Coresh; Neil R Powe; Tariq Shafi Journal: Nephrol Dial Transplant Date: 2020-05-01 Impact factor: 5.992
Authors: E Lars Penne; Neelke C van der Weerd; Peter J Blankestijn; Marinus A van den Dorpel; Muriel P C Grooteman; Menso J Nubé; Piet M Ter Wee; Renée Lévesque; Michiel L Bots Journal: Clin J Am Soc Nephrol Date: 2009-11-12 Impact factor: 8.237
Authors: Enric Vilar; Andrew C Fry; David Wellsted; James E Tattersall; Roger N Greenwood; Ken Farrington Journal: Clin J Am Soc Nephrol Date: 2009-10-09 Impact factor: 8.237