Literature DB >> 17622252

Filling out the Hippo pathway.

Leslie J Saucedo1, Bruce A Edgar.   

Abstract

How cell numbers are controlled during organ development is a problem that is still in need of answers. Recent studies in Drosophila melanogaster have delineated a novel signalling pathway, the Hippo pathway, which has an important role in restraining cell proliferation and promoting apoptosis in differentiating epithelial cells. Much like cancer cells, cells that contain mutations for components of the Hippo pathway proliferate inappropriately and have a competitive edge in genetically mosaic tissues. Although poorly characterized in mammals, several components of the Hippo pathway seem to be tumour suppressors in humans.

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Year:  2007        PMID： 17622252     DOI： 10.1038/nrm2221

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  147 in total

1.  c-Abl antagonizes the YAP oncogenic function.

Authors:  R Keshet; J Adler; I Ricardo Lax; M Shanzer; Z Porat; N Reuven; Y Shaul
Journal:  Cell Death Differ       Date:  2014-10-31       Impact factor: 15.828

2.  Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene.

Authors:  Shashikiran Donthamsetty; Vishakha S Bhave; Corrine S Kliment; William C Bowen; Wendy M Mars; Aaron W Bell; Rachel E Stewart; Anne Orr; Chuanyue Wu; George K Michalopoulos
Journal:  Hepatology       Date:  2011-01-06       Impact factor: 17.425

3.  The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase.

Authors:  Chen-Ying Liu; Zheng-Yu Zha; Xin Zhou; Heng Zhang; Wei Huang; Di Zhao; Tingting Li; Siew Wee Chan; Chun Jye Lim; Wanjin Hong; Shimin Zhao; Yue Xiong; Qun-Ying Lei; Kun-Liang Guan
Journal:  J Biol Chem       Date:  2010-09-21       Impact factor: 5.157

4.  Myc Function in Drosophila.

Authors:  Paola Bellosta; Peter Gallant
Journal:  Genes Cancer       Date:  2010-06-01

Review 5.  VGLL4 is a transcriptional cofactor acting as a novel tumor suppressor via interacting with TEADs.

Authors:  Xiaochong Deng; Lin Fang
Journal:  Am J Cancer Res       Date:  2018-06-01       Impact factor: 6.166

6.  Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma.

Authors:  Yun-Yong Park; Bo Hwa Sohn; Randy L Johnson; Myoung-Hee Kang; Sang Bae Kim; Jae-Jun Shim; Lingegowda S Mangala; Ji Hoon Kim; Jeong Eun Yoo; Cristian Rodriguez-Aguayo; Sunila Pradeep; Jun Eul Hwang; Hee-Jin Jang; Hyun-Sung Lee; Rajesha Rupaimoole; Gabriel Lopez-Berestein; Woojin Jeong; Inn Sun Park; Young Nyun Park; Anil K Sood; Gordon B Mills; Ju-Seog Lee
Journal:  Hepatology       Date:  2015-11-26       Impact factor: 17.425

7.  The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.

Authors:  Dawang Zhou; Benjamin D Medoff; Lanfen Chen; Lequn Li; Xian-feng Zhang; Maria Praskova; Matthew Liu; Aimee Landry; Richard S Blumberg; Vassiliki A Boussiotis; Ramnik Xavier; Joseph Avruch
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-10       Impact factor: 11.205

8.  The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP.

Authors:  Katherine Striedinger; Scott R VandenBerg; Gilson S Baia; Michael W McDermott; David H Gutmann; Anita Lal
Journal:  Neoplasia       Date:  2008-11       Impact factor: 5.715

Review 9.  The Hippo-YAP pathway: new connections between regulation of organ size and cancer.

Authors:  Bin Zhao; Qun-Ying Lei; Kun-Liang Guan
Journal:  Curr Opin Cell Biol       Date:  2008-11-18       Impact factor: 8.382

Review 10.  Development and morphogenesis of the Wolffian/epididymal duct, more twists and turns.

Authors:  Avenel Joseph; Humphrey Yao; Barry T Hinton
Journal:  Dev Biol       Date:  2008-11-01       Impact factor: 3.582
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